{"created":"2023-07-27T06:39:05.186581+00:00","id":27395,"links":{},"metadata":{"_buckets":{"deposit":"7dad23ff-c806-40ab-af9a-744077739fb1"},"_deposit":{"created_by":3,"id":"27395","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27395"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027395","sets":["1777:1778:1779"]},"author_link":["47568","536","47569","94","47511","47571","47570","74","47573","47572"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"291","bibliographicPageStart":"286","bibliographicVolumeNumber":"382","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The assembly of RAD51 recombinase on DNA substrates at sites of breakage is essential for their repair by homologous recombination repair (HRR). The signaling pathway that triggers RAD51 assembly at damage sites to form subnuclear foci is unclear. Here, we provide evidence that c-ABL, a tyrosine kinase activated by DNA damage which phosphorylates RAD51 on Tyr-315, works at a previously unrecognized, proximal step to initiate RAD51 assembly. We first show that c-ABL associates with chromatin after DNA damage in a manner dependent on its kinase activity. Using RAD51 mutants that are unable to oligomerize to form a nucleoprotein filament, we separate RAD51 assembly on DNA to form foci into two steps: stable chromatin association followed by oligomerization. We show that phosphorylation on Tyr-315 by c-ABL is required for chromatin association of oligomerization-defective RAD51 mutants, but is insufficient to restore oligomerization. Our findings suggest a new model for the regulation of early steps of HRR. © 2009 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所がん分子細胞制御","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2009.03.020","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/00006291X","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00564395","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Hiroko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Popova, Milena"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fleury, Fabrice"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Masahiko"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Hayashi, Naoyuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sakane, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurumisaka, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Venkitaraman, Ashok R."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Masayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Ken-ichi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-YAMAMOTO-K-286.pdf","filesize":[{"value":"737.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-YAMAMOTO-K-286.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27395/files/CA-PR-YAMAMOTO-K-286.pdf"},"version_id":"7a4c5058-5e0c-4366-8dea-c01f4036670f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"c-ABL tyrosine kinase stabilizes RAD51 chromatin association","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"c-ABL tyrosine kinase stabilizes RAD51 chromatin association"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27395","relation_version_is_last":true,"title":["c-ABL tyrosine kinase stabilizes RAD51 chromatin association"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:06:58.276325+00:00"}