{"created":"2023-07-27T06:39:05.229862+00:00","id":27396,"links":{},"metadata":{"_buckets":{"deposit":"45825620-dfc1-457c-bb4e-aeab1504d1b2"},"_deposit":{"created_by":3,"id":"27396","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27396"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027396","sets":["1777:1778:1779"]},"author_link":["47574","47578","118","47575","49","330","47577","47576"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"19","bibliographicPageEnd":"7892","bibliographicPageStart":"7884","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Cancer Research"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Accumulating evidence indicates the crucial contribution of chronic inflammation to various types of carcinogenesis, including colon carcinoma associated with ulcerative colitis and asbestosis-induced malignant mesothelioma. Ulcerative colitis-associated colon carcinogenesis can be recapitulated in mice by azoxymethane administration followed by repetitive dextran sulfate sodium ingestion. In the course of this carcinogenesis process, the expression of a macrophage-tropic chemokine, CCL2, was enhanced together with intracolonic massive infiltration of macrophages, which were a major source of cyclooxygenase (COX)-2, a crucial mediator of colon carcinogenesis. Mice deficient in CCL2-specific receptor, CCR2, exhibited less macrophage infiltration and lower tumor numbers with attenuated COX-2 expression. Moreover, CCL2 antagonists decreased intracolonic macrophage infiltration and COX-2 expression, attenuated neovascularization, and eventually reduced the numbers and size of colon tumors, even when given after multiple colon tumors have developed. These observations identify CCL2 as a crucial mediator of the initiation and progression of chronic colitis-associated colon carcinogenesis and suggest that targeting CCL2 may be useful in treating colon cancers, particularly those associated with chronic inflammation. ©2009 American Association for Cancer Research.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所がん病態制御","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for Cancer Research"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1158/0008-5472.CAN-09-1451","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00598557","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0008-5472","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Popivanova, Boryana Konstantinova"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kostadinova, Feodora Ivanova"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furuichi, Kengo"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Shamekh, Mohamed M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Toshikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wada, Takashi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Egashira, Kensuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mukaida, Naofumi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-MUKAIDA-N-7884.pdf","filesize":[{"value":"10.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-MUKAIDA-N-7884.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27396/files/CA-PR-MUKAIDA-N-7884.pdf"},"version_id":"8dc2699f-db56-4f87-958b-16d9428188e8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27396","relation_version_is_last":true,"title":["Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:06:55.838460+00:00"}