{"created":"2023-07-27T06:39:07.000371+00:00","id":27438,"links":{},"metadata":{"_buckets":{"deposit":"f04dd6b5-a77f-4ad0-bb10-e8e368cc305e"},"_deposit":{"created_by":3,"id":"27438","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27438"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027438","sets":["1777:1778:1779"]},"author_link":["47718","227","2328","47716","30684","274","47717","48174","2313","47719","47720","47636","26701"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1681","bibliographicPageStart":"1671","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"The EMBO journal"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小熊, 圭祐"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"大島, 浩子"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"仲, 一仁"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"平尾, 敦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"大島, 正伸"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The activation of Wnt/β-catenin signalling has an important function in gastrointestinal tumorigenesis. It has been suggested that the promotion of Wnt/β-catenin activity beyond the threshold is important for carcinogenesis. We herein investigated the role of macrophages in the promotion of Wnt/β-catenin activity in gastric tumorigenesis. We found β-catenin nuclear accumulation in macrophage-infiltrated dysplastic mucosa of the K19-Wnt1 mouse stomach. Moreover, macrophage depletion in Apc Δ716 mice resulted in the suppression of intestinal tumorigenesis. These results suggested the role of macrophages in the activation of Wnt/β-catenin signalling, which thus leads to tumour development. Importantly, the conditioned medium of activated macrophages promoted Wnt/β-catenin signalling in gastric cancer cells, which was suppressed by the inhibition of tumour necrosis factor (TNF)-α. Furthermore, treatment with TNF-α induced glycogen synthase kinase 3β (GSK3β) phosphorylation, which resulted in the stabilization of β-catenin. We also found that Helicobacter infection in the K19-Wnt1 mouse stomach caused mucosal macrophage infiltration and nuclear β-catenin accumulation. These results suggest that macrophage-derived TNF-α promotes Wnt/β-catenin signalling through inhibition of GSK3β, which may contribute to tumour development in the gastric mucosa. © 2008 European Molecular Biology Organization | All Rights Reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所がん幹細胞研究センター","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00027425","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/emboj.2008.105","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1460-2075","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oguma, Keisuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Oshima, Hiroko"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Aoki, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchio, Ryusei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naka, Kazuhito"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakamura, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirao, Atsushi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Saya, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taketo, Makoto Mark"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oshima, Masanobu"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-OSHIMA-M-1671.pdf","filesize":[{"value":"5.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-OSHIMA-M-1671.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27438/files/CA-PR-OSHIMA-M-1671.pdf"},"version_id":"ebd115bc-c17a-464a-9d99-9f083f57af7f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells."}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27438","relation_version_is_last":true,"title":["Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells."],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T10:47:36.050780+00:00"}