{"created":"2023-07-27T06:39:07.259774+00:00","id":27444,"links":{},"metadata":{"_buckets":{"deposit":"4cb8c594-f196-4246-b1bf-ae2276dea9b7"},"_deposit":{"created_by":3,"id":"27444","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27444"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027444","sets":["1777:1778:1779"]},"author_link":["47738","142","47739","195","15392","53","1180","47740"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"358","bibliographicPageStart":"350","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Genes to Cells"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The ultraviolet B (UVB) component of sunlight can cause severe damage to skin cells and even induce skin cancer. Growing evidence indicates that the UVB-induced signaling network is complex and involves diverse cellular processes. In this study, we investigated the role of c-Jun NH2-terminal kinase-associated leucine zipper protein (JLP), a scaffold protein for mitogen-activated protein kinase (MAPK) signaling cascades, in UVB-induced apoptosis. We found that UVB-induced skin epidermal apoptosis was prevented in Jlp knockout (KO) as well as in keratinocyte-specific Jlp KO mice. Analysis of the repair of UVB-induced DNA damage over time showed no evidence for the involvement of JLP in this process. In contrast, UVB-stimulated p38 MAPK activation in the skin was impaired in both Jlp KO and keratinocyte-specific Jlp KO mice. Moreover, topical treatment of UVB-irradiated mouse skin with a p38 inhibitor significantly suppressed the epidermal apoptosis in wild-type mice, but not in Jlp KO mice. Our findings suggest that JLP in skin basal keratinocytes plays an important role in UVB-induced apoptosis by modulating p38 MAPK signaling pathways. This is the first study to show a critical role for JLP in an in vivo response to environmental stimulation. © 2014 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/gtc.12135","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11623816","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1365-2443","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Enkhtuya, Radnaa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Tokiharu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Wakasugi, Mitsuo"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tuvshintugs, Baljinnyam"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyata, Hirofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Takeshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Matsunaga, Tsukasa"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yoshioka, Katsuji"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-YOSHIOKA-K-350.pdf","filesize":[{"value":"399.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-YOSHIOKA-K-350.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27444/files/CA-PR-YOSHIOKA-K-350.pdf"},"version_id":"a5dccf49-e624-41b1-bc93-55896ccd1f0c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27444","relation_version_is_last":true,"title":["The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:06:19.106284+00:00"}