{"created":"2023-07-27T06:39:07.604907+00:00","id":27452,"links":{},"metadata":{"_buckets":{"deposit":"b04535ad-cd46-4c64-a2cd-e7cdac58d325"},"_deposit":{"created_by":3,"id":"27452","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27452"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027452","sets":["1777:1778:1779"]},"author_link":["31151","47764","10118"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"396","bibliographicPageStart":"393","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"日本消化器外科学会雑誌 = The Japanese journal of gastroenterological surgery"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"今回,tumor dormancyを目的とした化学療法として,CPT-11の低用量投与法を試みた.低用量投与としては,25mg/m^2をday1,2,3/wで毎週継続するレジメとした.対象は,転移性胃癌と大腸癌,それぞれ8例,計16例である.その結果,低用量投与では副作用が激減し,grade3以上の骨髄抑制を3例(18.6%)をみるのみであった.また投与期間は著明に延長し,平均7.1月で従来法1.8月の約4倍にも相当した.抗腫瘍効果では,奏効率が50%と従来法の29.4%と大きな差は認められなかったが,time to progression (TTP)では,低用量群では平均5.3月と,従来法群の1.6月と3倍以上の差が認められた.またmedian survival time (MST)もそれぞれ11.5月,4.5月と有意差が認められた.以上本法は,縮小よりもTTPの延長から生存期間の延長をもたらす化学療法,いわゆる\"dormant chemotherapy\"と考えられた. We tried a new regimen with frequent administration of low-dose CPT-11 to reduce side effects without any impairing efficacy, administering 25mg/m^2 of CPT-11 continuously on days 1, 2, and 3 of each week in 8 patients with metastatic colon cancer and 8 with metastatic gastric cancer. Grade-3 marrow depression occurred in only 3 patients. Of our 16 patients, 8 had PR, 7 had NC, and 1 had PD, showing a 50% efficacy. Time to progression (TTP) averaged 5.3 months and median survival time (MST) 11.5 months, significantly superior to rusults for the conventional CPT-11 regimen. These results suggest that the low-dose CPT-11 regimen is promising and potential by reduces side eflects and strengthens the antitumor effect, inducing prolonged TTP and survival.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本消化器外科学会 = Japanese Society of Gastroenterological Surgery"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jsgs.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110001341036","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本消化器外科学会 | 本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00192066","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-9768","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 豊"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"北方, 秀一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"磨伊, 正義"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-TAKAHASHI-Y-393.pdf","filesize":[{"value":"427.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-TAKAHASHI-Y-393.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27452/files/CA-PR-TAKAHASHI-Y-393.pdf"},"version_id":"416b297f-259c-4372-8515-990e670bd420"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tumor dormancy therapyを目指した化学療法,CPT-11による\"Dormant chemotherapy\"","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tumor dormancy therapyを目指した化学療法,CPT-11による\"Dormant chemotherapy\""},{"subitem_title":"Low-Dose CPT-11 for Inducing Tumor Dormancy in Metastatic Colon and Gastric Cancers for","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27452","relation_version_is_last":true,"title":["Tumor dormancy therapyを目指した化学療法,CPT-11による\"Dormant chemotherapy\""],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:06:11.534663+00:00"}