{"created":"2023-07-27T06:39:07.776909+00:00","id":27456,"links":{},"metadata":{"_buckets":{"deposit":"a666ad0e-3939-4273-b178-612580e106c8"},"_deposit":{"created_by":3,"id":"27456","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27456"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027456","sets":["1777:1778:1779"]},"author_link":["47776","124","24008","23232","47775"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"255","bibliographicPageStart":"251","bibliographicVolumeNumber":"455","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Vinculin regulates a variety of cellular functions partly through stabilization of tumor suppressor PTEN. In order to study the role of vinculin in tumor progression other than PTEN stabilization, vinculin was knocked down in PTEN-deficient squamous cell carcinoma HSC-4 cells. Knockdown of vinculin induced phenotypical change by reducing cell-cell and cell-extracellular matrix adhesions, and enhanced MT1-MMP expression at transcription level and subsequent cell migration. Up-regulation of MT1-MMP transcription by vinculin knockdown was abrogated by ERK inhibition. These results suggest that vinculin negatively regulates malignant phenotype of tumor cells including MT1-MMP transcription through MEK/ERK pathway.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Academic Press / Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2014.10.154","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00564395","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshimoto, Taisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takino, Takahisa"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Li, Zichen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Domoto, Takahiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sato, Hiroshi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-TAKINO-T-251.pdf","filesize":[{"value":"650.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-TAKINO-T-251.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27456/files/CA-PR-TAKINO-T-251.pdf"},"version_id":"0dd5b547-ea08-43bf-8327-28abc784e1b7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27456","relation_version_is_last":true,"title":["Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:06:06.995632+00:00"}