{"created":"2023-07-27T06:39:09.837553+00:00","id":27501,"links":{},"metadata":{"_buckets":{"deposit":"dd163b06-77d4-481c-9948-f29768761533"},"_deposit":{"created_by":3,"id":"27501","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27501"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027501","sets":["1777:1778:1779"]},"author_link":["142","47931","47932","1180","47930","36","33"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"19","bibliographicPageEnd":"2811","bibliographicPageStart":"2805","bibliographicVolumeNumber":"589","bibliographic_titles":[{"bibliographic_title":"FEBS Letters"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"JNK/stress-activated protein kinase-associated protein 1 (JSAP1) and JNK-associated leucine zipper protein (JLP) are structurally related scaffolding proteins that are highly expressed in the brain. Here, we found that JSAP1 and JLP play functionally redundant and essential roles in mouse cerebellar Purkinje cell (PC) survival. Mice containing PCs with deletions in both JSAP1 and JLP exhibited PC axonal dystrophy, followed by gradual, progressive neuronal loss. Kinesin-1 cargoes accumulated selectively in the swollen axons of Jsap1/Jlp-deficient PCs. In addition, autophagy inactivation in these mice markedly accelerated PC degeneration. These findings suggest that JSAP1 and JLP play critical roles in kinesin-1-dependent axonal transport, which prevents brain neuronal degeneration. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period (12 mouths)","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B. V."}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.febslet.2015.08.024","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/00145793","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Elsevier (CC-BY NC ND)"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00642943","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-5793","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Tokiharu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ishikawa, Momoe"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshihara, Toru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakazato, Ryota"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Higashida, Haruhiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Asano, Masahide"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yoshioka, Katsuji"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-YOSHIOKA-K-2805.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-YOSHIOKA-K-2805.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27501/files/CA-PR-YOSHIOKA-K-2805.pdf"},"version_id":"75b7b649-b0a4-45cc-9d9b-7e077610c9b9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27501","relation_version_is_last":true,"title":["Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:05:28.943091+00:00"}