{"created":"2023-07-27T06:39:10.308454+00:00","id":27512,"links":{},"metadata":{"_buckets":{"deposit":"e9a809be-05dd-45ff-bc2a-ad4f4d53ff32"},"_deposit":{"created_by":3,"id":"27512","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27512"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027512","sets":["1777:1778:1779"]},"author_link":["1818","47964","47963","1444","256","83","478"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1827","bibliographicPageStart":"1822","bibliographicVolumeNumber":"101","bibliographic_titles":[{"bibliographic_title":"Cancer Science"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今村, 龍"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"木下, 健"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"須田, 貴司"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The adaptor protein ASC (also called TMS1) links certain NLR proteins (e.g., NLRC4, NLRP3) and caspases. It is involved in the chemosensitivity of tumor cells and inflammation. Here, we found that ASC activation using NLRC4 mimicry or an autoinflammatory disease-associated NLRP3 mutant induced necrosis in COLO205 colon adenocarcinoma cells, but induced caspase-8-dependent apoptosis in NUGC-4 stomach cancer cells. As the Fas ligand induced caspase-8-dependent apoptosis in COLO205 cells, caspase-8 was intact in this cell line. ASC-mediated necrosis was preceded by lysosomal leakage, and diminished by inhibitors for vacuolar H+-ATPase, cathepsins, and calpains but not by inhibitors for caspase-8, or aspartic proteases, suggesting that lysosomes and certain proteases were involved in this process. Finally, growing tumors of transplanted human cancer cells in nude mice were eradicated by the activation of endogenous ASC in the tumor cells, irrespective of the form of cell death. Thus, ASC mediates distinct forms of cell death in different cell types, and is a promising target for cancer therapy. (Cancer Sci 2010). © 2010 Japanese Cancer Association.","subitem_description_type":"Abstract"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00027499","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Cancer Association / Blackwell Publishing Ltd"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1349-7006.2010.01610.x","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jca.gr.jp/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Japanese Cancer Association 日本癌学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11808050","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-9032","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Motani, Kou"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kawase, Kouji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imamura, Ryu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kinoshita, Takeshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kushiyama, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suda, Takashi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-SUDA-T-1822.pdf","filesize":[{"value":"522.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SUDA-T-1822.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27512/files/CA-PR-SUDA-T-1822.pdf"},"version_id":"ca2c68d2-ade4-4ca4-b507-fb3ca5232007"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27512","relation_version_is_last":true,"title":["Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T10:50:57.471619+00:00"}