{"created":"2023-07-27T06:39:10.393991+00:00","id":27514,"links":{},"metadata":{"_buckets":{"deposit":"985c732e-f1ad-40c6-8640-f6edf3a43f70"},"_deposit":{"created_by":3,"id":"27514","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27514"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027514","sets":["1777:1778:1779"]},"author_link":["227","26701"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"23","bibliographicPageStart":"13","bibliographic_titles":[{"bibliographic_title":"Inflammation and Immunity in Cancer"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Accumulating evidence has indicated that chronic inflammation is associated with a variety of diseases, including cancer, heart attacks, Alzheimer’s and other diseases. In the cancer research field, the association of inflammatory infiltration with cancer has been known histologically for a long time. Recent studies have indicated that macrophages and other immune cells infiltrate cancer tissues, expressing cytokines, chemokines and growth factors, thereby constructing an inflammatory microenvironment. In such a microenvironment, nuclear factor (NF)-κB is activated, which contributes to the growth and survival of cancer cells. Moreover, it has also been shown that NF-κB activation is associated with the acquisition of stem cell properties by cancer cells. Using inflammation-associated gastric cancer model mice (Gan mice), we have shown that tumor necrosis factor (TNF)-α signaling is activated in the inflammatory microenvironment and plays a tumor-promoting role by inducing Noxo1 in tumor cells. Taken together, these results indicate that regulation of chronic inflammation in tumor tissues would be an effective preventive and/or therapeutic strategy against cancer development and malignant progression. © 2015, Springer Japan. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"[Book Chapter]","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Japan"}]},"item_4_relation_10":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"978-443155327-4","subitem_relation_type_select":"ISBN"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"978-443155326-7","subitem_relation_type_select":"ISBN"}}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/978-4-431-55327-4_2","subitem_relation_type_select":"DOI"}}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oshima, Hiroko"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Oshima, Masanobu"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-OSHIMA-M-13.pdf","filesize":[{"value":"495.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-OSHIMA-M-13.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27514/files/CA-PR-OSHIMA-M-13.pdf"},"version_id":"77a9abae-99cd-44aa-91ec-579e32e838c0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PGE2-associated inflammation and gastrointestinal tumorigenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PGE2-associated inflammation and gastrointestinal tumorigenesis"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27514","relation_version_is_last":true,"title":["PGE2-associated inflammation and gastrointestinal tumorigenesis"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:05:15.077831+00:00"}