| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
|
|
タイトル |
MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6 |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00027503 |
|
ID登録タイプ |
JaLC |
| 著者 |
Yoshida, Akiyo
Kitajima, Shunsuke
Li, Fengkai
Cheng, Chaoyang
Takegami, Yujiro
Kohno, Susumu
Wan, Yuan Song
Hayashi, Naoyuki
Muranaka, Hayato
Nishimoto, Yuuki
Nagatani, Naoko
Nishiuchi, Takumi
Thai, Tran C
Suzuki, Sawako
Nakao, Shinji
Tanaka, Tomoaki
Hirose, Osamu
Barbie, David A.
Takahashi, Chiaki
|
| 著者別表示 |
北嶋, 俊輔
河野, 晋
林, 直之
西内, 巧
中尾, 眞二
高橋, 智聡
|
| 書誌情報 |
Oncotarget
巻 8,
号 8,
p. 13872-13885,
発行日 2017-01-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1949-2553 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.18632/oncotarget.14681 |
| 出版者 |
|
|
出版者 |
Impact Journals LLC |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
We established an in vitro cell culture system to determine novel activities of the retinoblastoma (Rb) protein during tumor progression. Rb depletion in p53-null mouse-derived soft tissue sarcoma cells induced a spherogenic phenotype. Cells retrieved from Rb-depleted spheres exhibited slower proliferation and less efficient BrdU incorporation, however, much higher spherogenic activity and aggressive behavior. We discovered six miRNAs, including mmu-miR-18a, -25, -29b, -140, -337, and -1839, whose expression levels correlated tightly with the Rb status and spherogenic activity. Among these, mmu-miR-140 appeared to be positively controlled by Rb and to antagonize the effect of Rb depletion on spherogenesis and tumorigenesis. Furthermore, among genes potentially targeted by mmu-miR-140, Il-6 was upregulated by Rb depletion and downregulated by mmu-mir-140 overexpression. Altogether, we demonstrate the possibility that mmu-mir-140 mediates the Rb function to downregulate Il-6 by targeting its 3'-untranslated region. Finally, we detected the same relationship among RB, hsa-miR-140 and IL-6 in a human breast cancer cell line MCF-7. Because IL-6 is a critical modulator of malignant features of cancer cells and the RB pathway is impaired in the majority of cancers, hsa-miR-140 might be a promising therapeutic tool that disrupts linkage between tumor suppressor inactivation and pro-inflammatory cytokine response. |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
Supplementary Table1 and Supplementary Table2: We offer the table data with an Excel file |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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