{"created":"2023-07-27T06:39:10.479240+00:00","id":27516,"links":{},"metadata":{"_buckets":{"deposit":"02249c50-6af0-453c-a2c0-8d3afbd3cbb8"},"_deposit":{"created_by":3,"id":"27516","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27516"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027516","sets":["1777:1778:1779"]},"author_link":["302","47979","47974","74398","47511","47970","47977","71","77805","47972","47978","47969","69496","47981","47976","47975","47971","24856","47870","47982","2653","47973","105983","47980"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"13885","bibliographicPageStart":"13872","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Oncotarget"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北嶋, 俊輔"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"河野, 晋"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"林, 直之"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"西内, 巧"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"中尾, 眞二"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"高橋, 智聡"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We established an in vitro cell culture system to determine novel activities of the retinoblastoma (Rb) protein during tumor progression. Rb depletion in p53-null mouse-derived soft tissue sarcoma cells induced a spherogenic phenotype. Cells retrieved from Rb-depleted spheres exhibited slower proliferation and less efficient BrdU incorporation, however, much higher spherogenic activity and aggressive behavior. We discovered six miRNAs, including mmu-miR-18a, -25, -29b, -140, -337, and -1839, whose expression levels correlated tightly with the Rb status and spherogenic activity. Among these, mmu-miR-140 appeared to be positively controlled by Rb and to antagonize the effect of Rb depletion on spherogenesis and tumorigenesis. Furthermore, among genes potentially targeted by mmu-miR-140, Il-6 was upregulated by Rb depletion and downregulated by mmu-mir-140 overexpression. Altogether, we demonstrate the possibility that mmu-mir-140 mediates the Rb function to downregulate Il-6 by targeting its 3'-untranslated region. Finally, we detected the same relationship among RB, hsa-miR-140 and IL-6 in a human breast cancer cell line MCF-7. Because IL-6 is a critical modulator of malignant features of cancer cells and the RB pathway is impaired in the majority of cancers, hsa-miR-140 might be a promising therapeutic tool that disrupts linkage between tumor suppressor inactivation and pro-inflammatory cytokine response.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Supplementary Table1 and Supplementary Table2: We offer the table data with an Excel file","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00027503","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals LLC"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.18632/oncotarget.14681","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1949-2553","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Akiyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitajima, Shunsuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Li, Fengkai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Cheng, Chaoyang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takegami, Yujiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Susumu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Wan, Yuan Song"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Naoyuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Muranaka, Hayato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimoto, Yuuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagatani, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishiuchi, Takumi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Thai, Tran C"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Sawako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Shinji"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tanaka, Tomoaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirose, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Barbie, David A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Chiaki"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-TAKAHASHI-C-Supplementary_Table2.xlsx","filesize":[{"value":"78.2 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mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27516","relation_version_is_last":true,"title":["MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T08:47:34.161907+00:00"}