{"created":"2023-07-27T06:39:10.993808+00:00","id":27528,"links":{},"metadata":{"_buckets":{"deposit":"0abcf22d-2f8b-449e-8a2f-e9c74dd04d5b"},"_deposit":{"created_by":3,"id":"27528","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27528"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027528","sets":["1777:1778:1779"]},"author_link":["48004","141","48005","47999"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"505","bibliographicPageStart":"499","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"Cancer Science"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mutations in Kirsten rat-sarcoma (KRAS) are well appreciated to be major drivers of human cancers through dysregulation of multiple growth and survival pathways. Similar to many other non-kinase oncogenes and tumor suppressors, efforts to directly target KRAS pharmaceutically have not yet materialized. As a result, there is broad interest in an alternative approach to develop therapies that induce synthetic lethality in cancers with mutant KRAS, therefore exposing the particular vulnerabilities of these cancers. Fueling these efforts is our increased understanding into the biology driving KRAS mutant cancers, in particular the important pathways that mutant KRAS governs to promote survival. In this mini-review, we summarize the latest approaches to treat KRAS mutant cancers and the rationale behind them. © 2014 The Authors.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"がん進展制御研究所","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Cancer Association / Blackwell Publishing Ltd"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/cas.12383","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jca.gr.jp/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Japanese Cancer Association 日本癌学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11808050","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-9032","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ebi, Hiromichi"}],"nameIdentifiers":[{"nameIdentifier":"47999","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00645145","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00645145"},{"nameIdentifier":"00645145","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000645145"}]},{"creatorNames":[{"creatorName":"Faber, Anthony C."}],"nameIdentifiers":[{"nameIdentifier":"48004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Engelman, Jeffrey A."}],"nameIdentifiers":[{"nameIdentifier":"48005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yano, Seiji"}],"nameIdentifiers":[{"nameIdentifier":"141","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30294672","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30294672"},{"nameIdentifier":"30294672","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30294672"},{"nameIdentifier":"30294672","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030294672"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-EBI-H-499.pdf","filesize":[{"value":"958.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-EBI-H-499.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27528/files/CA-PR-EBI-H-499.pdf"},"version_id":"a30f7c1f-4f0f-4805-85a3-4c57071f8adf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Not just gRASping at flaws: Finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Not just gRASping at flaws: Finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27528","relation_version_is_last":true,"title":["Not just gRASping at flaws: Finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-06-25T04:59:41.365444+00:00"}