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Fibroblasts, an inconspicuous but essential player in colon cancer development and progression
https://doi.org/10.24517/00027522
https://doi.org/10.24517/00027522169953ca-ce8f-4705-a264-01dd0e7459b2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CA-PR-MUKAIDA-N-5301.pdf (770.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-10-05 | |||||||||
| タイトル | ||||||||||
| タイトル | Fibroblasts, an inconspicuous but essential player in colon cancer development and progression | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00027522 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Mukaida, Naofumi
× Mukaida, Naofumi× Sasaki, So-ichiro |
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| 著者別表示 |
向田, 直史
× 向田, 直史
× 佐々木, 宗一郎
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| 書誌情報 |
World Journal of Gastroenterology 巻 22, 号 23, p. 5301-5316, 発行日 2016-06-21 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1007-9327 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11690631 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.3748/wjg.v22.i23.5301 | |||||||||
| 出版者 | ||||||||||
| 出版者 | WJG Press / Baishideng Publishing Group Co., Limited | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Tumor microenvironments have a crucial role in cancer initiation and progression, and share many molecular and pathological features with wound healing process. Unless treated, tumors, however, do not heal in contrast to wounds that heal within a limited time framework. Wounds heal in coordination of a myriad of types of cells, particularly endothelial cells, leukocytes, and fibroblasts. Similar sets of cells also contribute to cancer initiation and progression, and as a consequence, anti-cancer treatment strategies have been proposed and tested by targeting endothelial cells and/or leukocytes. Compared with endothelial cells and leukocytes, less attention has been paid to the roles of cancer-associated fibroblasts (CAFs), fibroblasts present in tumor tissues, because their heterogeneity hinders the elucidation on them at cellular and molecular levels. Here, we will discuss the origin of CAFs and their crucial roles in cancer initiation and progression, and the possibility to develop a novel type of anti-cancer treatment by manipulating the migration and functions of CAFs. © 2016 Baishideng Publishing Group Inc. All rights reserved. | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
