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Increased Level of Serum Vascular Endothelial Growth Factor by Long-Term Exposure to Hypergravity
https://doi.org/10.24517/00027525
https://doi.org/10.24517/000275250cb6f8b3-7488-4a76-b197-7ff1e42f5fc9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CA-PR-OSHIMA-M-309.pdf (215.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-10-05 | |||||||||
| タイトル | ||||||||||
| タイトル | Increased Level of Serum Vascular Endothelial Growth Factor by Long-Term Exposure to Hypergravity | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00027525 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Oshima, Masanobu
× Oshima, Masanobu× Suzki, Hiromi× Guo, Xiaoying× Oshima, Hiroko |
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| 著者別表示 |
大島, 正伸
× 大島, 正伸
× 大島, 浩子
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| 書誌情報 |
Experimental Animals 巻 56, 号 4, p. 309-313, 発行日 2007-01-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1341-1357 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11032321 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1538/expanim.56.309 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 日本実験動物学会 = Japanese Association for Laboratory Animal Science | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | We have previously demonstrated that short-term exposure to hypergravity at 2G for 4 h induces expression of cyclooxygenase-2 (COX-2) in the mouse heart. Moreover, expression of vascular endothelial growth factor (VEGF) is also induced in the heart in a COX-2-dependent manner. Here, we demonstrate that long-term exposure of mice to 2G for 24 h resulted in a significant increase of serum VEGF level, although expression of COX-2 and VEGF in the heart decreased to the 1G-control level. Moreover, increase of serum VEGF was not suppressed by treatment with COX-2 inhibitor, indicating that VEGF was induced in a COX-2-independent manner. These results suggest that gravitational force contributes to maintenance of the serum VEGF level. | |||||||||
| 権利 | ||||||||||
| 権利情報 | Copyright (c) 2007 日本実験動物学会 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://ci.nii.ac.jp/naid/130000068034 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://japanlinkcenter.org/JST.JSTAGE/expanim/56.309 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.jalas.jp/ | |||||||||
