{"created":"2023-07-27T06:39:11.814207+00:00","id":27547,"links":{},"metadata":{"_buckets":{"deposit":"fc7bcaca-649e-4c03-b1b8-f2bb84238c8a"},"_deposit":{"created_by":3,"id":"27547","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27547"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027547","sets":["1777:1778:1779"]},"author_link":["48062","142","48061","2674","48056","48058","48055","48065","48066","48063","48057","48067","48064","48060","48059"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"484","bibliographicPageStart":"475","bibliographicVolumeNumber":"114","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Investigation"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"善岡, 克次"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Receptor activator of NF-κB ligand (RANKL) plays an essential role in osteoclast formation and bone resorption. Although genetic and biochemical studies indicate that RANKL regulates osteoclast differentiation by activating receptor activator of NF-κB and associated signaling molecules, the molecular mechanisms of RANKL-regulated osteoclast differentiation have not yet been fully established. We investigated the role of the transcription factor c-Jun, which is activated by RANKL, in osteoclastogenesis using transgenic mice expressing dominant-negative c-Jun specifically in the osteoclast lineage. We found that the transgenic mice manifested severe osteopetrosis due to impaired osteoclastogenesis. Blockade of c-Jun signaling also markedly inhibited soluble RANKL-induced osteoclast differentiation in vitro. Overexpression of nuclear factor of activated T cells 1 (NFAT1) (NFATc2/ NFATp) or NFAT2 (NFATc1/NFATc) promoted differentiation of osteoclast precursor cells into tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated osteoclast-like cells even in the absence of RANKL. Overexpression of NFAT1 also markedly transactivated the TRAP gene promoter. These osteoclastogenic activities of NFAT were abrogated by overexpression of dominant-negative c-Jun. Importantly, osteoclast differentiation and induction of NFAT2 expression by NFAT1 overexpression or soluble RANKL treatment were profoundly diminished in spleen cells of the transgenic mice. Collectively, these results indicate that c-Jun signaling in cooperation with NFAT is crucial for RANKL-regulated osteoclast differentiation.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所がん分子細胞制御","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00027534","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1172/JCI200419657","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1172/JCI200419657","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jci.org/articles/view/19657","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2004, The American Society for Clinical Investigation"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9738","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikeda, Fumiyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimura, Riko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsubara, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Sakae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Jun-ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Reddy, Sakamuri V."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hata, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiraga, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kukita, Toshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshioka, Katsuji"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Rao, Anjana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoneda, Toshiyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-YOSHIOKA-K-475.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-YOSHIOKA-K-475.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27547/files/CA-PR-YOSHIOKA-K-475.pdf"},"version_id":"4705f6a2-ba19-416b-bf55-4430f93830c6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-requlated osteoclast differentiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-requlated osteoclast differentiation"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27547","relation_version_is_last":true,"title":["Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-requlated osteoclast differentiation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:05:58.042147+00:00"}