{"created":"2023-07-27T06:39:11.857525+00:00","id":27548,"links":{},"metadata":{"_buckets":{"deposit":"fda2bf8b-fc92-46f5-805e-a9fd727fb9de"},"_deposit":{"created_by":3,"id":"27548","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27548"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027548","sets":["1777:1778:1779"]},"author_link":["48070","177","48071","65","48069","48068","48073","48072"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-11-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"22","bibliographicPageEnd":"8578","bibliographicPageStart":"8572","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Cancer Research"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川上, 和之"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"源, 利成"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Wnt and Hedgehog signaling pathways play central roles in embryogenesis, stem cell maintenance, and tumorigenesis. However, the mechanisms by which these two pathways interact are not well understood. Here, we identified a novel mechanism by which Wnt signaling pathway stimulates the transcriptional output of Hedgehog signaling. Wnt/β-catenin signaling induces expression of an RNA-binding protein, CRD-BP, which in turn binds and stabilizes GLI1 mRNA, causing an elevation of GLI1 expression and transcriptional activity. The newly described mode of regulation of GLI1 seems to be important to several functions of Wnt, including survival and proliferation of colorectal cancer cells. ©2009 American Association for Cancer Research.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所分子標的がん医療研究開発センター","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00027535","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for Cancer Research"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1158/0008-5472.CAN-09-1500","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00598557","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0008-5472","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Noubissi, Felicite K."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goswami, Srikanta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sanek, Nicholas A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Kazuyuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Minamoto, Toshinari"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Moser, Amy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Grinblat, Yevgenya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Spiegelman, Vladimir S."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-MINAMOTO-T-8572.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-MINAMOTO-T-8572.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27548/files/CA-PR-MINAMOTO-T-8572.pdf"},"version_id":"f3948187-ce61-4185-8cc0-38252fd47e1c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Wnt signaling stimulates transcriptional outcome of the hedgehog pathway by stabilizing GLI1 mRNA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Wnt signaling stimulates transcriptional outcome of the hedgehog pathway by stabilizing GLI1 mRNA"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27548","relation_version_is_last":true,"title":["Wnt signaling stimulates transcriptional outcome of the hedgehog pathway by stabilizing GLI1 mRNA"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:05:53.190744+00:00"}