{"created":"2023-07-27T06:39:11.986756+00:00","id":27551,"links":{},"metadata":{"_buckets":{"deposit":"5f44b8b6-b9dd-4c81-8a76-f15f352d3d2f"},"_deposit":{"created_by":3,"id":"27551","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27551"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027551","sets":["1777:1778:1779"]},"author_link":["124","79","20357","2781","96268","95412","48080","2907","23232","47461"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"526","bibliographicPageStart":"517","bibliographicVolumeNumber":"139","bibliographic_titles":[{"bibliographic_title":"Journal of Biochemistry"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"滝野, 隆久 "}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"宮森, 久志"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"吉崎, 智一"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"古川, 仞"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"佐藤, 博"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Amyloid-β precursor protein (APP) was identified on expression cloning from a human placenta cDNA library as a gene product that modulates the activity of membrane-type matrix metalloproteinase-1 (MT1-MMP). Co-expression of MT1-MMP with APP in HEK293T cells induced cleavage and shedding of the APP ectodomain when co-expressed with APP adaptor protein Fe65. Among the MT-MMPs tested, MT3-MMP and MT5-MMP also caused efficient APP shedding. The recombinant APP protein was cleaved by MT3-MMP in vitro at the A463-M 464, N579-M580, H622-S 623, and H685-Q686 peptide bonds, which included a cleavage site within the amyloid β peptide region known to produce a C-terminal fragment. The Swedish-type mutant of APP, which produces a high level of amyloid β peptide, was more effectively cleaved by MT3-MMP than wild-type APP in both the presence and absence of Fe65; however, amyloid β peptide production was not affected by MT3-MMP expression. Expression of MT3-MMP enhanced Fe65-dependent transactivation by APP fused to the Gal4 DNA-binding and transactivation domains. These results suggest that MT1-MMP, MT3-MMP and MT5-MMP should play an important role in the regulation of APP functions in tissues including the central nervous system. © 2006 The Japanese Biochemical Society.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所がん病態制御","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00027538","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本生化学会 = Japanese Biochemical Society"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jb/mvj054","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1093/jb/mvj054","subitem_relation_type_select":"DOI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2006 The Japanese Biochemical Society"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00694073","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-924X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ahmad, Munirah"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takino, Takahisa"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Miyamori, Hisashi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yoshizaki, Tomokazu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Furukawa, Mitsuru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sato, Hiroshi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-SATO-H-517.pdf","filesize":[{"value":"364.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SATO-H-517.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27551/files/CA-PR-SATO-H-517.pdf"},"version_id":"9fa80a36-22a0-4403-9d8a-478f96d1b99c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cleavage of amyloid-β precursor protein (APP) by membrane-type matrix metalloproteinases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cleavage of amyloid-β precursor protein (APP) by membrane-type matrix metalloproteinases"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27551","relation_version_is_last":true,"title":["Cleavage of amyloid-β precursor protein (APP) by membrane-type matrix metalloproteinases"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:05:48.233114+00:00"}