{"created":"2023-07-27T06:39:28.051712+00:00","id":27925,"links":{},"metadata":{"_buckets":{"deposit":"6c6baf45-fc46-4858-8b02-ae97d8e21651"},"_deposit":{"created_by":3,"id":"27925","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27925"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027925","sets":["1777:1780:1800:1801"]},"author_link":["797"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウスモデルを用いた消化器がんの発がん分子機序に関する基礎研究"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2010","bibliographicPageEnd":"12","bibliographicPageStart":"11","bibliographicVolumeNumber":"平成22年度","bibliographic_titles":[{"bibliographic_title":"金沢大学がん研究所 共同研究成果報告書"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Runx3 遺伝子欠損マウスの胃上皮と、Runx3 遺伝子欠損マウスから樹立した胃上皮細胞株を 解析した結果、胃がん発がん過程には、Runx3 の不活性化によって惹起されるWnt のがん化シ グナルが必須で、その過程でCdx2 の発現が誘導され、胃上皮細胞に腸型化がもたらされるも のと考えられた。ヒト胃がん検体より見出されたRUNX3 の点変異体RUNX3(R122C)は、 -catenin/TCFs と相互作用できず、Wnt のがん化シグナルを抑制できない変異体であることが判 明した。","subitem_description_type":"Abstract"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん研究所 = Cancer Research Institute of Kanazawa University"}]},"item_9_relation_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BA90820956","subitem_relation_type_select":"NCID"}}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.kanazawa-u.ac.jp/~ganken/","subitem_relation_type_select":"URI"}}]},"item_9_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Cancer Research Institute of Kanazawa University"}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-com-report-2010-11-12.pdf","filesize":[{"value":"354.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-com-report-2010-11-12.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27925/files/CA-com-report-2010-11-12.pdf"},"version_id":"e3f31719-9caa-479a-9426-61ecaa682d4d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"転写因子Runx3 の胃がん発がんの分子機序における役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"転写因子Runx3 の胃がん発がんの分子機序における役割"}]},"item_type_id":"9","owner":"3","path":["1801"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27925","relation_version_is_last":true,"title":["転写因子Runx3 の胃がん発がんの分子機序における役割"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:00:34.477479+00:00"}