{"created":"2023-07-27T06:39:28.179759+00:00","id":27928,"links":{},"metadata":{"_buckets":{"deposit":"682fd53b-f4ed-4b16-9b1c-a83fc7208961"},"_deposit":{"created_by":3,"id":"27928","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27928"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027928","sets":["1777:1780:1800:1801"]},"author_link":["154"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2010","bibliographicPageEnd":"18","bibliographicPageStart":"17","bibliographicVolumeNumber":"平成22年度","bibliographic_titles":[{"bibliographic_title":"金沢大学がん研究所 共同研究成果報告書"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、CD133 をマーカーとする幹細胞様グリオーマ細胞の高い浸潤能を規定する分子 を探索した。グリオーマ組織中のCD133 陽性細胞において普遍的にMT1-MMP とintegrin α3 が高発現していることを見出した。ヒト膠芽腫組織において、浸潤グリオーマ細胞にMT1-MMP とintegrin α3 の局在を認めた。Integrin α3 の発現とグリオーマ細胞の浸潤能は正の相関 を示し、その下流のシグナルとしてextracellular signal-regulated kinase（ERK）1/2 が示 された。integrin α3 はERK1/2 の活性を介して幹細胞様グリオーマ細胞の遊走・浸潤能を亢 進させることが示唆された。","subitem_description_type":"Abstract"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん研究所 = Cancer Research Institute of Kanazawa University"}]},"item_9_relation_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BA90820956","subitem_relation_type_select":"NCID"}}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.kanazawa-u.ac.jp/~ganken/","subitem_relation_type_select":"URI"}}]},"item_9_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Cancer Research Institute of Kanazawa University"}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-com-report-2010-17-18.pdf","filesize":[{"value":"383.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-com-report-2010-17-18.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27928/files/CA-com-report-2010-17-18.pdf"},"version_id":"d973ce00-99b8-4e3e-80a5-25f9e7663c4d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"悪性脳腫瘍におけるMT1-MMP とCD133 との相互作用の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"悪性脳腫瘍におけるMT1-MMP とCD133 との相互作用の解析"},{"subitem_title":"MT1-MMP の機能解析と分子標的治療法の開発","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["1801"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27928","relation_version_is_last":true,"title":["悪性脳腫瘍におけるMT1-MMP とCD133 との相互作用の解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:00:30.640320+00:00"}