{"created":"2023-07-27T06:39:30.116276+00:00","id":27973,"links":{},"metadata":{"_buckets":{"deposit":"06910cf6-2515-4a61-b87c-8be0be0dd1e0"},"_deposit":{"created_by":3,"id":"27973","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27973"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027973","sets":["1777:1780:1813:1816"]},"author_link":["30662"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ケモカインを分子標的とした治療法の開発"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2012","bibliographicPageEnd":"45","bibliographicPageStart":"43","bibliographicVolumeNumber":"平成24年度","bibliographic_titles":[{"bibliographic_title":"金沢大学がん進展制御研究所 共同研究成果報告書"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"種々の臓器において炎症反応の遷延化，すなわち慢性炎症が発癌において重要なステップであることが知られており，皮膚発がんにおいても同様である．そこで，二段階皮膚腫瘍形成モデルを用いて皮膚発がんにおける，CX3CL1-CX3CR1の病態生理学的役割を解析した． 8週齢・雄C57BL/6マウス(WT)およびCX3CR1遺伝子欠損マウス(KO)の背部にDMBA（100 μg/200μl acetone）塗布後，TPA(30 μg/200 μl acetone)を週に２回，２０週連続塗布して腫瘍形成を誘導する．肉眼的に乳頭腫および皮膚腫瘍の形成を観察したところ，KOマウスでは乳頭腫形成が有意に少なかった．また，マクロファージおよびＴ細胞浸潤もKOマウスで有意に減少していたしたがって，CX3CL1-CX3CR1シグナルがマクロファージおよびＴ細胞浸潤に密接に関連し，皮膚発がんにおける重要性が明らかとなった．","subitem_description_type":"Abstract"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所 = Cancer Research Institute of Kanazawa University"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.kanazawa-u.ac.jp/~ganken/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-report-2012-43-45_24seika-16.pdf","filesize":[{"value":"747.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-report-2012-43-45_24seika-16.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27973/files/CA-report-2012-43-45_24seika-16.pdf"},"version_id":"61027bbe-3fd4-4c50-a90d-4d9a26aeeb40"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"皮膚発がんにおける骨髄由来細胞とケモカインの包括的役割解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮膚発がんにおける骨髄由来細胞とケモカインの包括的役割解析"}]},"item_type_id":"9","owner":"3","path":["1816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27973","relation_version_is_last":true,"title":["皮膚発がんにおける骨髄由来細胞とケモカインの包括的役割解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T20:59:37.353024+00:00"}