{"created":"2023-07-27T06:39:30.202295+00:00","id":27975,"links":{},"metadata":{"_buckets":{"deposit":"9e6ac468-e7ea-4d55-aa84-8c1bbff15a6c"},"_deposit":{"created_by":3,"id":"27975","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27975"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027975","sets":["1777:1780:1813:1816"]},"author_link":["1613"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"HGF-Met系を中心とするがん転移・薬剤耐性のメカニズムと制がん・創薬研究"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2012","bibliographicPageEnd":"50","bibliographicPageStart":"48","bibliographicVolumeNumber":"平成24年度","bibliographic_titles":[{"bibliographic_title":"金沢大学がん進展制御研究所 共同研究成果報告書"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HGFβ・ベンゼン誘導体複合体のX線構造に基づき、辺縁に正電荷及び負電荷を有するサブポケット（S2）を狙ったStructure-Based Drug Design (SBDD)を行ったが、活性向上には至らなかった。このことはS2サブポケットを埋めるだけでは活性向上が難しいことを示唆している。そこで、HGFβ-Metの相互作用に関わる他のサブポケット（S1, S1’）を同時に阻害するペプチド性化合物を分子モデリングにより設計した。これらの化合物は弱いながら阻害活性を示した。今後、エントロピーロスを最小限にするためにコンホメーションを分子内で固定化した化合物を設計して高活性HGFアンタゴニストの創出を目指す。","subitem_description_type":"Abstract"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所 = Cancer Research Institute of Kanazawa University"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.kanazawa-u.ac.jp/~ganken/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-report-2012-48-50_24seika-18.pdf","filesize":[{"value":"549.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-report-2012-48-50_24seika-18.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27975/files/CA-report-2012-48-50_24seika-18.pdf"},"version_id":"5e3a8d59-74ef-41fb-9085-09885c4a1a06"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HGF-Metの活性化機構に基づく分子創薬研究－Ｘ線構造を基盤とした最適化研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HGF-Metの活性化機構に基づく分子創薬研究－Ｘ線構造を基盤とした最適化研究"}]},"item_type_id":"9","owner":"3","path":["1816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27975","relation_version_is_last":true,"title":["HGF-Metの活性化機構に基づく分子創薬研究－Ｘ線構造を基盤とした最適化研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T20:59:34.296769+00:00"}