{"created":"2023-07-27T06:39:30.673689+00:00","id":27986,"links":{},"metadata":{"_buckets":{"deposit":"918c9d99-afb5-4dd3-a540-46af59945ec5"},"_deposit":{"created_by":3,"id":"27986","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27986"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027986","sets":["1777:1780:1813:1816"]},"author_link":["154"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2012","bibliographicPageEnd":"78","bibliographicPageStart":"77","bibliographicVolumeNumber":"平成24年度","bibliographic_titles":[{"bibliographic_title":"金沢大学がん進展制御研究所 共同研究成果報告書"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、膠芽腫患者由来の9種類の膠芽腫幹細胞株を使用しNotch阻害剤であるγ-セクレターゼ阻害剤(MRK-003以後MRK)の有効性をin vitroで評価した。MRKにより膠芽腫幹細胞の細胞増殖抑制、アポトーシス促進、幹細胞形質の喪失を認めた。膠芽腫幹細胞株にはMRK高感受性群と低感受性群が存在した。CD44の発現量が高く、CD133の発現量が低い膠芽腫幹細胞様細胞にMRKは有効でありCD44およびCD133発現量はNotch阻害剤感受性のバイオマーカーになりうると考えられた。","subitem_description_type":"Abstract"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所 = Cancer Research Institute of Kanazawa University"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.kanazawa-u.ac.jp/~ganken/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-report-2012-77-78_24seika-8.pdf","filesize":[{"value":"693.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-report-2012-77-78_24seika-8.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27986/files/CA-report-2012-77-78_24seika-8.pdf"},"version_id":"ca5297a3-24fc-48c3-bddb-94ad5fa0c231"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Notchシグナルを標的としたグリオーマ幹細胞の制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Notchシグナルを標的としたグリオーマ幹細胞の制御"},{"subitem_title":"がん幹細胞を標的とした薬剤スクリーニング法の開発に関する研究","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["1816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27986","relation_version_is_last":true,"title":["Notchシグナルを標的としたグリオーマ幹細胞の制御"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T20:59:17.627275+00:00"}