{"created":"2023-07-27T06:39:31.360709+00:00","id":28002,"links":{},"metadata":{"_buckets":{"deposit":"1f71f109-fd4c-467f-8cfd-513d8034fe69"},"_deposit":{"created_by":3,"id":"28002","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"28002"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00028002","sets":["1777:1780:1813:1817"]},"author_link":["30662"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ケモカインを分子標的とした治療法の開発"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2011","bibliographicPageEnd":"25","bibliographicPageStart":"23","bibliographicVolumeNumber":"平成23年度","bibliographic_titles":[{"bibliographic_title":"金沢大学がん進展制御研究所 共同研究成果報告書"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"二段階皮膚腫瘍形成モデルを用いて皮膚発がんにおける，CX3CL1-CX3CR1の病態生理学的役割を解析した。 8週齢・雄C57BL/6マウス(WT)およびCX3CR1遺伝子欠損マウス(KO)の背部にDMBA（100 μg/200μl acetone）塗布後，TPA(30 μg/200 μl acetone)を週に２回，２０週連続塗布して腫瘍形成を誘導する。肉眼的に乳頭腫および皮膚腫瘍の形成を観察したところ，KOマウスでは乳頭腫形成が有意に少なかった。したがって，皮膚発がんにおけるCX3CL1-CX3CR1シグナルの重要性が明らかとなった。","subitem_description_type":"Abstract"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所 = Cancer Research Institute of Kanazawa University"}]},"item_9_relation_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BA90820956","subitem_relation_type_select":"NCID"}}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.kanazawa-u.ac.jp/~ganken/","subitem_relation_type_select":"URI"}}]},"item_9_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Cancer Research Institute of Kanazawa University"}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-com-report-2011-23-25.pdf","filesize":[{"value":"621.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-com-report-2011-23-25.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/28002/files/CA-com-report-2011-23-25.pdf"},"version_id":"210057c2-0d81-4039-8a05-9de94ce97237"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"皮膚発がんにおけるケモカインの病態生理学的役割解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮膚発がんにおけるケモカインの病態生理学的役割解析"}]},"item_type_id":"9","owner":"3","path":["1817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"28002","relation_version_is_last":true,"title":["皮膚発がんにおけるケモカインの病態生理学的役割解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T20:58:58.527894+00:00"}