{"created":"2023-07-27T06:40:30.333803+00:00","id":29350,"links":{},"metadata":{"_buckets":{"deposit":"1b2f5f02-3e6e-41f2-94de-ad95e7b73c28"},"_deposit":{"created_by":3,"id":"29350","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"29350"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00029350","sets":["1979:1980:1981"]},"author_link":["50451","50446","50448","50455","50449","35","50453","50454","50456","50447","50450","50445","324","50443","15004","26423","50452","50444"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"223","bibliographicPageStart":"217","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Zoological Science"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Fish scales are a form of calcified tissue similar to that found in human bone. In medaka scales, we detected both osteoblasts and osteoclasts and subsequently developed a new scale assay system. Using this system, we analyzed the osteoblastic and osteoclastic responses under 2-, 3-, and 4-gravity (G) loading by both centrifugation and vibration. After loading for 10 min, the scales from centrifugal and vibration loading were incubated for 6 and 24 hrs, respectively, after which the osteoblastic and osteoclastic activities were measured. Osteoblastic activity significantly increased under 2- to 4-G loading by both centrifugation and vibration. In contrast, we found that osteoclastic activity significantly decreased under 2- and 3-G loading in response to both centrifugation and vibration. Under 4-G loading, osteoclastic activity also decreased on centrifugation, but significantly increased under 4-G loading by vibration, concomitant with markedly increased osteoblastic activity. Expression of the receptor activator of the NF-αB ligand (RANKL), an activation factor of osteoclasts expressed in osteoblasts, increased significantly under 4-G loading by vibration but was unchanged by centrifugal loading. A protein sequence similar to osteoprotegerin (OPG), which is known as an osteoclastogenesis inhibitory factor, was found in medaka using our sequence analysis. The ratio of RANKL/OPG-like mRNAs in the vibration-loaded scales was significantly higher than that in the control scales, although there was no difference between centrifugal loaded scales and the control scales. Accordingly, medaka scales provide a useful model by which to analyze bone metabolism in response to physical strain. © 2013 Zoological Society of Japan.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Zoological Society of Japan = 日本動物学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2108/zsj.30.217","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.zoology.or.jp/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 Zoological Society of Japan"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10545874","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0289-0003","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yano, Sachiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Kei-ichiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Satoh, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hattori, Atsuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekiguchi, Toshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikegame, Mika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Omori, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakawa, Kazuichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Chiba, Atsuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasayama, Yuichi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ejiri, Sadakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mikuni-Takagaki, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mishima, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Funahashi, Hisayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Nobuo"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"NA-PR-YANO-SUZUMKI-217.pdf","filesize":[{"value":"728.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"NA-PR-YANO-SUZUMKI-217.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/29350/files/NA-PR-YANO-SUZUMKI-217.pdf"},"version_id":"26f6f61f-cbd7-4d15-a5bd-b3f69b5813ad"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Static and dynamic hypergravity responses of osteoblasts and osteoclasts in medaka scales","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Static and dynamic hypergravity responses of osteoblasts and osteoclasts in medaka scales"}]},"item_type_id":"4","owner":"3","path":["1981"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"29350","relation_version_is_last":true,"title":["Static and dynamic hypergravity responses of osteoblasts and osteoclasts in medaka scales"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:31:18.704744+00:00"}