@article{oai:kanazawa-u.repo.nii.ac.jp:00029351,
 author = {Suzuki, Nobuo and Maruyama, Yusuke and Nakano, Masaki and Hattori, Atsuhiko and Honda, Masato and Shimasaki, Yohei and Sekiguchi, Toshio and Mishima, Hiroyuki and Wada, Shigehito and Srivastav, Ajai K. and Hayakawa, Kazuichi and Oshima, Yuji},
 issue = {1},
 journal = {Journal of the Faculty of Agriculture, Kyushu University},
 month = {Feb},
 note = {We recently demonstrated that prostaglandin E2 PG¿ increases osteoclastic activity and induces bone resorption in both in vitro and in vivo experiments using goldfish. In the fish reproductive period, the plasma calcium (Ca) level in female teleosts increases remarkably to make vitellogenin, which is a major component of egg protein and a Ca-binding protein. In this period, however, there is no reported relationship between PGE2 and Ca metabolism in fish. To clarify the Ca metabolism in fish reproduction, we examined plasma PGE2 and Ca levels and measured tartrate-resistant acid phosphatase (TRAP) activities as an indicator of osteoclastic activity in goldfish. Plasma PGE2 levels in the reproductive stage significantly increased as compared with those in non-reproductive stages. Also, both plasma Ca and TRAP increased in the reproductive stage. Significant positive correlations were recognized between plasma Ca and the gonad somatic index (r=0.81, p<0.001), plasma Ca and plasma PGE2 levels (r=0.635, p<0.05), and plasma Ca and plasma TRAP activities (r=0.584, p<0.05) from the analysis using samples of both reproductive and nonreproductive stages. Taking these data into consideration, we suggested that PGE, acts on osteoclasts and increases plasma Ca as a result of osteoclastic bone resorption, and we concluded that PGE, is an important hormone in Ca metabolism during fish reproduction.},
 pages = {97--101},
 title = {Increased prostaglandin e2 has a positive correlation with plasma calcium during goldfish reproduction},
 volume = {59},
 year = {2014}
}