@article{oai:kanazawa-u.repo.nii.ac.jp:00029439,
 author = {Takahashi, Hideya and Suzuki, Nobuo and Takagi, Chiyo and Ikegame, Mika and Yamamoto, Toshio and Takahashi, Akiyoshi and Moriyama, Shunsuke and Hattori, Atsuhiko and Sakamoto, Tatsuya},
 issue = {7},
 journal = {Zoological Science},
 month = {Jul},
 note = {In teleosts, prolactin is involved in calcium regulation, but its role in scale/bone metabolism Is unclear. Using the in-vitro system with goldfish scales developed recently, we explored the effects of teleost prolactin, growth hormone, and somatolactin on osteoclasts and osteoblasts. Addition of prolactin at concentrations of 0.01-100 ng/ml reduced osteoclastic activity, partly via osteoclast apoptosis, after 6-18 h incubation. Conversely, growth hormone and somatolactin at a concentration of 100 ng/ml increased osteoclastic activity after 18 h incubation, indicating the specificity of the inhibitory effect of prolactin on osteoclastic activity. On the other hand, these three hormones promoted osteoblastic activity at concentrations of 10-100 ng/ml. The results from this study are the first demonstration of direct effects of prolactin on scale/bone metabolism and osteoclastic activity in a teleost. © 2008 Zoological Society of Japan.},
 pages = {739--745},
 title = {Prolactin inhibits osteoclastic activity in the goldfish scale: A novel direct action of prolactin in teleosts},
 volume = {25},
 year = {2008}
}