@article{oai:kanazawa-u.repo.nii.ac.jp:00030979,
 author = {Higashida, Haruhiro and Salmina, Alla and Hashii, Minako and Yokoyama, Shigeru and Zhang, Jia-Sheng and Noda, Mami and Zhong, Zen-Guo},
 issue = {20},
 journal = {FEBS Letters},
 month = {Sep},
 note = {ADP-ribosyl cyclase activity in the crude membrane fraction of neuroblastoma × glioma NGPM1-27 hybrid cells was measured by monitoring [3H] cyclic ADP-ribose (cADPR) formation from [3H] NAD+. Bradykinin (BK) at 100 nM increased ADP-ribosyl cyclase activity by about 2.5-fold. Application of 300 nM BK to living NGPM1-27 cells decreased NAD+ to 78% of the prestimulation level at 30 s. In contrast, intracellular cADPR concentrations were increased by 2-3-fold during the period from 30 to 120 s after the same treatment. Our results suggest that cADPR is one of the second messengers downstream of B2 BK receptors. © 2006 Federation of European Biochemical Societies., 金沢大学大学院医学系研究科脳細胞分子学},
 pages = {4857--4860},
 title = {Bradykinin activates ADP-ribosyl cyclase in neuroblastoma cells: Intracellular concentration decrease in NAD and increase in cyclic ADP-ribose},
 volume = {580},
 year = {2006}
}