{"created":"2023-07-27T06:41:43.604549+00:00","id":31008,"links":{},"metadata":{"_buckets":{"deposit":"ad634186-ff53-444e-8a6c-44584600c031"},"_deposit":{"created_by":3,"id":"31008","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"31008"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00031008","sets":["2229:2230:2231"]},"author_link":["52733","111","52730","52732","224","52639","52734","52729","52731","91","36"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"379","bibliographicPageStart":"373","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Journal of neuroendocrinology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oxytocin in the hypothalamus is the biological basis of social recognition, trust, love and bonding. Previously, we showed that CD38, a proliferation marker in leukaemia cells, plays an important role in the hypothalamus in the process of oxytocin release in adult mice. Disruption of Cd38 (Cd38 (-/-)) elicited impairment of maternal behaviour and male social recognition in adult mice, similar to the behaviour observed in Oxt and oxytocin receptor (Oxtr) gene knockout (Oxt (-/-) and Oxtr (-/-), respectively) mice. Locomotor activity induced by separation from the dam was higher and the number of ultrasonic vocalisation calls was lower in Cd38 (-/-) than Cd38( +/+) pups. However, these behavioural changes were much milder than those observed in Oxt (-/-) and Oxtr (-/-) mice, indicating less impairment of social behaviour in Cd38 (-/-) pups. These phenotypes appeared to be caused by the high plasma oxytocin levels during development from the neonatal period to 3-week-old juvenile mice. ADP-ribosyl cyclase activity was markedly lower in the knockout mice from birth, suggesting that weaning for mice is a critical time window of plasma oxytocin differentiation. Breastfeeding was an important exogenous source of plasma oxytocin regulation before weaning as a result of the presence of oxytocin in milk and the dam's mammary glands. The dissimilarity between Cd38 (-/-) infant behaviour and those of Oxt (-/-) or Oxtr (-/-) mice can be explained partly by this exogenous source of oxytocin. These results suggest that secretion of oxytocin into the brain in a CD38-dependent manner may play an important role in the development of social behaviour.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley-Blackwell"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1365-2826.2010.01976.x","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11628285","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1365-2826","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Higashida, Haruhiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Lopatina, Olga A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshihara, T."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pichugina, Yu A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soumarokov, Andrei A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Munesue, Toshio"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Minabe, Yoshio"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kikuchi, Mitsuru"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Ono, Yasuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Korshunova, N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Salmina, Alla B."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-HIGASHIDA-H-373.pdf","filesize":[{"value":"234.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-HIGASHIDA-H-373.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/31008/files/ME-PR-HIGASHIDA-H-373.pdf"},"version_id":"563cd3ef-00fd-4460-8046-67219ebd3bb4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice."}]},"item_type_id":"4","owner":"3","path":["2231"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"31008","relation_version_is_last":true,"title":["Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T20:09:05.289252+00:00"}