{"created":"2023-07-27T06:41:44.140053+00:00","id":31020,"links":{},"metadata":{"_buckets":{"deposit":"fc0ba366-856f-4b80-a81d-e44098cc2d5f"},"_deposit":{"created_by":3,"id":"31020","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"31020"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00031020","sets":["2234:2235:2236"]},"author_link":["52774","69","52772","468","52771","52775","21901","210","52773"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"106","bibliographicPageStart":"102","bibliographicVolumeNumber":"257","bibliographic_titles":[{"bibliographic_title":"Journal of Neuroimmunology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Autoantibody against nicotinic acetylcholine receptor (nAChR) α3 subunit has been implicated in the pathogenesis of paraneoplastic neurological syndrome. To examine the effect of anti-α3 subunit autoantibody on cell-surface nAChRs, we established human embryonic kidney 293 cells stably co-expressing α3 and β4 subunits. Upon incubation with seropositive patient's serum, this cell line showed co-accumulation of patient's IgG and α3 subunits in the cytoplasm. These data support the hypothesis that anti-α3 subunit autoantibody induces internalization of cell-surface nAChRs and thereby impairs synaptic transmission. © 2012 Elsevier B.V. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jneuroim.2012.12.010","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/01655728","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA1045958X","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0165-5728","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobayashi, Shota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokoyama, Shigeru"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Maruta, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Negami, Masako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muroyama, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsumoto, Yasuhide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwasa, Kazuo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamada, Masahito"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Hiroaki"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HE-PR-YOSHIKAWA-H-102.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HE-PR-YOSHIKAWA-H-102.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/31020/files/HE-PR-YOSHIKAWA-H-102.pdf"},"version_id":"a0f3a9b9-3dee-4b86-9fa3-4b43c58c65e8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Autoantibody-induced internalization of nicotinic acetylcholine receptor α3 subunit exogenously expressed in human embryonic kidney cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Autoantibody-induced internalization of nicotinic acetylcholine receptor α3 subunit exogenously expressed in human embryonic kidney cells"}]},"item_type_id":"4","owner":"3","path":["2236"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"31020","relation_version_is_last":true,"title":["Autoantibody-induced internalization of nicotinic acetylcholine receptor α3 subunit exogenously expressed in human embryonic kidney cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T20:08:54.207746+00:00"}