{"created":"2023-07-27T06:44:16.527137+00:00","id":34444,"links":{},"metadata":{"_buckets":{"deposit":"97785702-575f-4641-ac95-79367515b877"},"_deposit":{"created_by":3,"id":"34444","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34444"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034444","sets":["2812:2813:2818"]},"author_link":["79652","200"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2012-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"医薬，農薬においては複素環は重要な役割を果たすことから，新規医薬，農薬など高付加価値物質の創生には複素環合成の新手法開拓が必須である。本研究では，窒素，酸素などのヘテロ原子を有してアトムエコノミカルな複素環合成に有効な1,3-双極子を活用し，「協奏的1,3-双極子付加環化の力量化」としてアゾメチンイミンの不斉1,3-双極子付加環化反応，「段階的（＝非協奏的）付加－環化を基盤とする集積反応系の確立」として，ニトロンへの不斉求核付加-環化反応，および「1,5-双極子のルネサンス」として，C,N-環状N’-アシルアゾメチンイミンの〔5+1〕環化反応など，３つの方向から複素環合成の革新を実現した。","subitem_description_type":"Abstract"},{"subitem_description":"The development of a practical and efficient method for construction of heterocycles is an essential part of programs to explore new medical and agrochemical agents. 1,3-Dipoles are important chemical species containing heteroatoms. We studied on innovative syntheses heterocycles utilizing 1,3-dipoles based on three strategies.\nWe designed a novel chiral reaction system possessing multi-metal centers utilizing tartaric acid ester as a chiral auxiliary. Based on this concept, we developed asymmetric 1,3-dipolar cycloadditions of azomethine imines to allylic alcohols. A strategy consisted of a stepwise addition to 1,3-dipoles, followed by cyclizaion was found to be an alternative and regiocontrolled pathway to synthesize of heterocycles. An asymmetric addition of acetylides to nitrones followed by cyclization was developed to give the corresponding optically active 4-isoxazolines. A novel [5+1] cycloaddition reaction of N’-acyl azomethine imines with isocyanides was also explored.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24350022, 研究期間(年度):2012-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「1, 3-双極子を活用する複素環合成の革新」研究成果報告書　課題番号24350022\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24350022/24350022seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工学域物質科学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034431","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80193853","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24350022/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24350022/24350022seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"SC-PR-UKAJI-Y-kaken 2016b-6p.pdf","filesize":[{"value":"387.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"SC-PR-UKAJI-Y-kaken 2016b-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34444/files/SC-PR-UKAJI-Y-kaken 2016b-6p.pdf"},"version_id":"da6db807-41ca-42c7-9f08-768f8711de16"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"1, 3-双極子を活用する複素環合成の革新","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1, 3-双極子を活用する複素環合成の革新"},{"subitem_title":"Innovation in Synthesis of Heterocycles Utilizing 1,3-Dipoles","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34444","relation_version_is_last":true,"title":["1, 3-双極子を活用する複素環合成の革新"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:05:32.348748+00:00"}