{"created":"2023-07-27T06:44:16.912001+00:00","id":34454,"links":{},"metadata":{"_buckets":{"deposit":"7f8587f6-2ed2-47a5-b341-9198feb0246d"},"_deposit":{"created_by":3,"id":"34454","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34454"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034454","sets":["2812:2813:2818"]},"author_link":["93714","245"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"遺伝子増幅は正常細胞が癌化する主な原因のひとつであり癌遺伝子増幅を知ることは分子標的治療を行う上で重要である。本研究では、日本人で頻度の高い胃癌、大腸癌、乳癌における46遺伝子についてmultiplex ligatioin-dependent probe amplification (MLPA)とfluoresence in situ hybridization を使って検索した結果、受容体チロシンキナーゼ遺伝子（ERBB2, FGFR1, FGFR2, EGFR, MET）　細胞増殖のG1-S制御遺伝子（CCNE1, CCND1、CDK6）、MYC, MDM2の増幅が見られた。","subitem_description_type":"Abstract"},{"subitem_description":"Gene amplification is a major type of genetic aberration found in human cancers of solid types.　The amplified genes so far have been useful targets or will be potential targets for molecular therapies. In this study, cancers of the stomach, breast and colon, which are frequent among Japanese, were examined for amplification of 46 genes by multiplex ligatioin-dependent probe amplification followed by fluoresence in situ hybridization. The results showed that the genes coding receptor tyrosine kinases (ERBB2, FGFR1, FGFR2, EGFR, MET), regulatory genes of cell cycle progression (CCNE1, CCND1, CDK6, MDM2), and gene coding a transcription factor (MYC) were found frequently amplified in these tumors.\nIn conclusion, combination of MLPA and FISH analysis is a feasible approach for obtaining the semi-comprehensive genetic information that is necessary for personalized molecular targeted therapy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25460452, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「MLPAとFISHを用いたヒト固形癌における遺伝子増幅の網羅的研究」研究成果報告書　課題番号25460452\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460452/25460452seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034441","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50160411","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460452/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460452/25460452seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-OOI-A-kaken 2016-5p.pdf","filesize":[{"value":"221.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-OOI-A-kaken 2016-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34454/files/ME-PR-OOI-A-kaken 2016-5p.pdf"},"version_id":"3b4f1355-4110-426e-8764-8cc4bc57ee21"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"MLPAとFISHを用いたヒト固形癌における遺伝子増幅の網羅的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MLPAとFISHを用いたヒト固形癌における遺伝子増幅の網羅的研究"},{"subitem_title":"Semi-comorehensive analysis of gene amplification in solid carcinomas using MLPA and FISH","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34454","relation_version_is_last":true,"title":["MLPAとFISHを用いたヒト固形癌における遺伝子増幅の網羅的研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:05:18.033293+00:00"}