{"created":"2023-07-27T06:44:17.056582+00:00","id":34457,"links":{},"metadata":{"_buckets":{"deposit":"6ce0a368-d2d3-4ef1-a3c8-83c2e7afdaaf"},"_deposit":{"created_by":3,"id":"34457","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34457"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034457","sets":["2812:2813:2818"]},"author_link":["52"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2型糖尿病では膵ランゲルハンス島β細胞からのインスリン分泌が徐々に低下し膵β細胞疲弊が生じる。このメカニズムを解明するため、高血糖による糖毒性物質advanced glycation end-products (AGE)とその細胞膜受容体receptor for AGE (RAGE)に着目し、レプチンシグナル不全のdb/dbマウスを使って検討した。また、マウス膵β細胞由来MIN6細胞を用いて糖脂肪毒性の影響を調べた。レプチン受容体シグナルの遮断と、遊離脂肪酸の暴露によって膵β細胞膜上のRAGE発現誘導が生じ、さらにAGE刺激によって膵β細胞はアポトーシス、インスリン分泌不全に陥ると結論された。","subitem_description_type":"Abstract"},{"subitem_description":"Glucolipotoxicity, which is exerted by free fatty acids (FFA) and prolonged hyperglycemia, is implicated in pancreatic β-cell failure in diabetes. We examined whether advanced glycation end-products (AGE) and RAGE contribute to β-cell failure in a type 2 diabetes mouse model. Pretreatment of FFA combined with a leptin antagonist induced RAGE expression, AGE-elicited apoptosis, and impaired glucose-stimulated insulin secretion by AGE in MIN6 cells. FFA elevation with concomitant AGE formation during prolonged hyperglycemia could cause β-cell damage through insufficient leptin action and subsequent RAGE induction in type 2 diabetes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25461335, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「2型糖尿病の膵β細胞不全におけるRAGE・糖脂肪毒性・レプチンの役割の解明」研究成果報告書　課題番号25461335\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461335/25461335seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034444","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00115198","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461335/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461335/25461335seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-YAMAMOTO-H-kaken 2016-6p.pdf","filesize":[{"value":"203.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMAMOTO-H-kaken 2016-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34457/files/ME-PR-YAMAMOTO-H-kaken 2016-6p.pdf"},"version_id":"bc64e6ba-4bb1-4b47-8709-54ec9507f045"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"2型糖尿病の膵β細胞不全におけるRAGE・糖脂肪毒性・レプチンの役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2型糖尿病の膵β細胞不全におけるRAGE・糖脂肪毒性・レプチンの役割の解明"},{"subitem_title":"To unveil mechanisms triggering pancreatic beta cell dysfunction in type 2 diabetes possibly via RAGE, glucolipotoxicity and insufficient leptin signaling","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34457","relation_version_is_last":true,"title":["2型糖尿病の膵β細胞不全におけるRAGE・糖脂肪毒性・レプチンの役割の解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:05:13.564742+00:00"}