{"created":"2023-07-27T06:44:18.209754+00:00","id":34482,"links":{},"metadata":{"_buckets":{"deposit":"5e91f652-f30e-483e-a090-d2a39a9a757c"},"_deposit":{"created_by":3,"id":"34482","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34482"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034482","sets":["2812:2813:2819"]},"author_link":["24011"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胎生期および出生直後のマウスの大脳皮質を単離しマイクロアレイ解析を行った。候補遺伝子リストの中から転写因子に焦点を絞り機能解析を行った。子宮内電気穿孔法を用いた遺伝子過剰発現実験、shRNAやノックアウトマウスを用いた遺伝子機能阻害実験を行った結果、樹状突起の形態成熟を負に制御する転写因子の同定に成功した。この遺伝子の発現を抑制すると樹状突起の成熟が促進されるだけではなく、神経細胞の移動が障害されることを見いだした。この結果は、神経細胞が適切なタイミングで生じることが重要であることを示唆している。","subitem_description_type":"Abstract"},{"subitem_description":"Using the cerebral cortex of embryonic and neonatal mice, microarray experiments were performed to identify the molecules whose expression levels changed before and after birth. Using in utero electroporation, loss- and gain-of-function studies were carried out, and we identified molecules that negatively regulated dendritic maturation. Furthermore, we found that the migration of immature neurons was also affected, suggesting that dendritic maturation should occur appropriate time point during development. Our results uncovered a novel regulatory mechanisms of neuronal maturation soon after birth.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25640032, 研究期間(年度):2013-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「出生により制御される遺伝子カスケードの解明」課題番号25640032\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25640032/25640032seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034469","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50303904"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50303904","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25640032/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25640032/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25640032/25640032seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25640032/25640032seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-KAWASAKI-H-kaken 2015-5p.pdf","filesize":[{"value":"252.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KAWASAKI-H-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34482/files/ME-PR-KAWASAKI-H-kaken 2015-5p.pdf"},"version_id":"56e47153-1a27-4faf-bb80-22cd2e9bcbde"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"出生により制御される遺伝子カスケードの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"出生により制御される遺伝子カスケードの解明"},{"subitem_title":"Mechanisms of brain formation regulated by birth","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34482","relation_version_is_last":true,"title":["出生により制御される遺伝子カスケードの解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T10:46:14.515864+00:00"}