{"created":"2023-07-27T06:44:18.400678+00:00","id":34486,"links":{},"metadata":{"_buckets":{"deposit":"05af2101-318f-48d8-ab7d-f17c56d597ba"},"_deposit":{"created_by":3,"id":"34486","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34486"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034486","sets":["2812:2813:2819"]},"author_link":["129","93957"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では，原発性胆汁性肝硬変（PBC）の障害胆管細胞には細胞老化に先行してオートファジー異常が認められること,PBCの胆管病変では、オートファジー異常がミトコンドリア抗原の異常発現をおこし、ミトコンドリア抗原に対する免疫反応異常の要因になる可能性があることが明らかになった。培養胆管細胞を用いた検討でも、ストレスによるミトコンドリアのオートファジーが検証された。さらに、PBCにおけるオートファジー異常, 細胞老化の発生には, 小胞体ストレスが関与することが示唆された.","subitem_description_type":"Abstract"},{"subitem_description":"This study revealed that deregulated autophagy followed by cellular senescence in biliary epithelial cells (BECs) may be closely related to the abnormal expression of mitochondrial antigens and following autoimmune pathogenesis in primary biliary cirrhosis (PBC). Cell culture study using mouse biliary epithelial cells supported the immunohistochemical findings in human PBC livers, suggesting autophagy of the mitochondrial proteins. Furthermore, this study disclosed that endoplasmic reticulum stress may play a role in the pathogenesis of deregulated autophagy and cellular senescence in biliary epithelial lesions in PBC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24590409, 研究期間(年度):2012-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「オートファジー異常に着目した原発性胆汁性肝硬変の新たな解析」課題番号24590409\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590409/24590409seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034473","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70225895"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70225895","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590409/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590409/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590409/24590409seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590409/24590409seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-SASAKI-M-kaken 2015-4p.pdf","filesize":[{"value":"228.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SASAKI-M-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34486/files/ME-PR-SASAKI-M-kaken 2015-4p.pdf"},"version_id":"b993a7ce-2a3c-4c23-b208-803f108a940a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オートファジー異常に着目した原発性胆汁性肝硬変の新たな解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オートファジー異常に着目した原発性胆汁性肝硬変の新たな解析"},{"subitem_title":"Novel approach to primary biliary cirrhosis putting focus on deregulated autophagy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34486","relation_version_is_last":true,"title":["オートファジー異常に着目した原発性胆汁性肝硬変の新たな解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T10:46:08.671980+00:00"}