{"created":"2023-07-27T06:44:18.832965+00:00","id":34495,"links":{},"metadata":{"_buckets":{"deposit":"1ee9f540-207e-4f85-99d4-ca33f6bf33ca"},"_deposit":{"created_by":3,"id":"34495","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34495"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034495","sets":["2812:2813:2819"]},"author_link":["23787"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2013-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"慢性ストレスはうつ病の主要なリスクファクタであるが，ストレスが誘導するうつ病(様)表現型の個体差とストレス負荷前に既に存在していた認知機能における個体差の関係については検討が少ない。本研究では，Progressive ratio (PR)スケジュールで訓練されたラットの欲求性オペラント行動における個体差に着目し，この指標が意欲の高さや意思決定スタイルの個体差を反映することを確認した。さらに，PR成績により分類された4つの亜群は，慢性ストレスに対してそれぞれ異なった反応性を短期的あるいは長期的に示した。これらの結果はストレス前の個体差からストレス反応性/脆弱性の個体差が予測できることを示唆した。","subitem_description_type":"Abstract"},{"subitem_description":"Although chronic stress has been widely used to induce depression-like phenotypes in preclinical studies, a few models have been developed to study causal relationship between the individual differences in the depression-like phenotypes and the pre-existing individual differences prior to stress exposure, which might genetically/epigenetically determine the fate of each animal after stress. We focused on a large inter-individual variability of a group of outbred rats in performance of an appetitive operant (leverpress) trained on a progressive ratio (PR) schedule. Based on the PR performance, we classified animals into 4 subgroups, which were found to show distinctive cognitive/behavioral characteristics. Moreover, the 4 subgroups revealed different behavioral responses to a chronic unpredictable stress (CUS) on short- and long-term bases. These results suggest that the individual differences in the pre-CUS PR performance can predict the distinctive post-CUS behavioral phenotypes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25860994, 研究期間(年度):2013-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「側坐核機能の個体差による大うつ病発症脆弱性および 治療薬反応性の予測」課題番号25860994\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860994/25860994seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034482","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20452097"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20452097","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860994/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860994/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860994/25860994seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860994/25860994seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井口, 善生"}],"nameIdentifiers":[{"nameIdentifier":"23787","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20452097","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20452097"},{"nameIdentifier":"20452097","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000020452097"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-IGUCHI-Y-kaken 2015-6p.pdf","filesize":[{"value":"974.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-IGUCHI-Y-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34495/files/ME-PR-IGUCHI-Y-kaken 2015-6p.pdf"},"version_id":"8efdf549-9fb1-415c-bff4-3b0c6e0da2a1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"側坐核機能の個体差による大うつ病発症脆弱性および 治療薬反応性の予測","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"側坐核機能の個体差による大うつ病発症脆弱性および 治療薬反応性の予測"},{"subitem_title":"Pre-stress performance in an operant learning predicts post-stress behavioral alterations in chronically stressed rats","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34495","relation_version_is_last":true,"title":["側坐核機能の個体差による大うつ病発症脆弱性および 治療薬反応性の予測"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-07-01T05:47:13.303543+00:00"}