{"created":"2023-07-27T06:44:19.648845+00:00","id":34513,"links":{},"metadata":{"_buckets":{"deposit":"6e51a512-4bf5-4db7-80a3-f5f3dfa23714"},"_deposit":{"created_by":3,"id":"34513","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34513"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034513","sets":["2812:2813:2820"]},"author_link":["282","88085"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"光線力学的治療（PDT）は低侵襲性のがん治療法の一つである。５-アミノレブリン酸（5-ALA）は腫瘍細胞内で光感受性物質であるプロトポルフィリンIX (PpIX) に代謝、活性化される新世代の光増感物質として注目されている。本研究では、5-ALAおよびPpIXの細胞膜輸送系に作用するPDT効果増強剤の開発を目指し、ヒトがん細胞を用いた感受性試験法により低分子化合物ライブラリーのスクリーニングを実施した。その結果、5-ALAと同時処理することにより細胞内PpIXが増加し、PDT効果を相乗的に増強する化合物、TX-816を見出した。今後、TX-816をリード化合物とする誘導体展開が期待される。","subitem_description_type":"Abstract"},{"subitem_description":"Protoporphyrin IX (PpIX)-dependent photodynamic diagnosis (PDD) and therapy (PDT) using 5-aminolevulinic acid (ALA-PDD and ALA-PDT) are widely recognized novel therapeutic strategies for the treatment of various cancers.Previously, we demonstrated that the balance between the influx of ALA through the transporter PEPT1 and the efflux of intracellular PpIX through the ABC transporter ABCG2 determines the sensitivity of cancer cells to ALA-PDT. Recently, we found that the Schiff base derivative TX-816 could significantly increase the effect of ALA-PDT. The ability of TX-816 to enhance the efficacy of ALA-PDT was markedly stronger than that of dipyridamole, which inhibits ABCG2 and equilibrative nucleoside transporters. Furthermore, TX-816 could recover the sensitivity to ALA-PDT in cancer cells with acquired resistance. These results indicate TX-816 is a potent lead compound to develop an ALA-PDT sensitizer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23501305, 研究期間(年度):2011–2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細胞膜輸送系の機能修飾に基づく光線力学的治療の効果増強法の基礎開発」課題番号23501305\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23501305/23501305seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034500","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30211783"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30211783","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23501305/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23501305/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23501305/23501305seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23501305/23501305seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-ENDO-Y-kaken 2014-5p.pdf","filesize":[{"value":"172.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-ENDO-Y-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34513/files/CA-PR-ENDO-Y-kaken 2014-5p.pdf"},"version_id":"cbd93a6d-a808-4e91-958f-7c30ba02ee55"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞膜輸送系の機能修飾に基づく光線力学的治療の効果増強法の基礎開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞膜輸送系の機能修飾に基づく光線力学的治療の効果増強法の基礎開発"},{"subitem_title":"Development of novel lead compounds with enhancing effect on ALA-based photodynamic therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34513","relation_version_is_last":true,"title":["細胞膜輸送系の機能修飾に基づく光線力学的治療の効果増強法の基礎開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:25:00.445561+00:00"}