{"created":"2023-07-27T06:44:20.127784+00:00","id":34524,"links":{},"metadata":{"_buckets":{"deposit":"d0a50e8e-5bdf-4079-9d90-55156ed61091"},"_deposit":{"created_by":3,"id":"34524","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34524"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034524","sets":["2812:2813:2820"]},"author_link":["21279"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Th2優位の免疫反応を示すLat Y136F knock-inマウス（Latマウス）がIgG4関連疾患（IgG4-RD）のモデル動物となり得るかを検討した。Latマウスは腎臓、膵臓、唾液腺においてヒトIgG4-RDと類似した病変を形成し、良好なステロイド反応性を示したことからIgG4-RDのモデルとなりうると考えられた。更に、APRILの意義を検討する為、LatマウスにAPRIL阻止抗体を投与した。APRIL阻止抗体投与群ではコントロール群と比較して腎臓の炎症が有意に抑制された。この結果より、APRILは少なくともIgG4関連腎臓病において病変形成に関与する因子である可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We evaluated whether Lat Y136F knock-in mice, which show Th2 predominant immunoreaction with increased serum IgG1, a counterpart of human IgG4, are a novel mice model for IgG4-related disease (IgG4-RD). Lat Y136F knock-in mice showed a similar pathology to that of human IgG4-RD in kidney, pancreas and salivary glands, and a good response to corticosteroid. These results suggested that Lat Y136F knock-in mice are a novel mice model for IgG4-RD. Next, we analyzed the role of APRIL in IgG4-RD using Lat Y136F knock-in mice. We administered APRIL blocking antibody to Lat Y136F knock-in mice, and found that the inflammation in kidney in an APRIL blocking antibody group was significantly decreased as compared to that in a control group. This result indicated that APRIL plays some role in the promotion of lesions at least in IgG4-related kidney disease.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23591460, 研究期間(年度):2011–2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「IgG4関連疾患の病態解明に向けて: Ｔ細胞機能異常に基づいたモデルマウスの確立」課題番号23591460\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591460/23591460seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034511","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20361983"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20361983","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591460/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591460/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591460/23591460seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591460/23591460seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-KAWANo-M-kaken 2014-6p.pdf","filesize":[{"value":"184.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KAWANo-M-kaken 2014-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34524/files/HO-PR-KAWANo-M-kaken 2014-6p.pdf"},"version_id":"e521b92d-d9a1-4d27-a15a-9f14e8fb77a7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"IgG4関連疾患の病態解明に向けて: Ｔ細胞機能異常に基づいたモデルマウスの確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IgG4関連疾患の病態解明に向けて: Ｔ細胞機能異常に基づいたモデルマウスの確立"},{"subitem_title":"Clarification of the etiopathogenesis of IgG4-related disease: Establishment of a mouse model based on abnormal T cell functional abnormalities","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34524","relation_version_is_last":true,"title":["IgG4関連疾患の病態解明に向けて: Ｔ細胞機能異常に基づいたモデルマウスの確立"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:24:45.359005+00:00"}