{"created":"2023-07-27T06:44:20.466044+00:00","id":34531,"links":{},"metadata":{"_buckets":{"deposit":"89531f8c-4285-4220-b9ce-b250dc933a58"},"_deposit":{"created_by":3,"id":"34531","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34531"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034531","sets":["2812:2813:2820"]},"author_link":["93531","10805"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2012-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腫瘍組織の中には“がん幹細胞”とよばれる少数の細胞が存在し、大多数の”分化”したがん細胞を殺傷しても、このがん幹細胞が生き残っている限り、がんは再発すると言われている。がん幹細胞は無限の増殖を示し、また薬剤排出能も高いため抗がん剤に対する抵抗性が高い。よって、がん幹細胞をいかに死滅させるかが、がんを根治するための鍵といえる。本研究では、がん幹細胞に特異的に集積する「標的化二酸化チタンナノ粒子」と後述する「超音波触媒法」とを融合した、非侵襲的かつ臓器機能温存型の新規がん治療法を構築した。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we applied sonodynamic therapy to cancer cells based on the delivery of titanium dioxide (TiO2) nanoparticles (NPs) modified with avidin protein, which preferentially discriminated cancerous cells from healthy cells. Subsequently, hydroxyl radicals were generated from the TiO2 NPs after activation by external ultrasound irradiation (TiO2/US treatment). Although 30% of the normal breast cells (human mammary epithelial cells) exhibited the uptake of avidin-modified TiO2 NPs, over 80% of the breast cancer cells (MCF-7) exhibited the uptake of avidin-TiO2 NPs. Next the effect of the TiO2/US treatment on MCF-7 cell growth was examined for up to 96 h after 1-MHz ultrasound was applied (0.1 W/cm2, 30 s) to cells that incorporated the TiO2 NPs. No apparent cell injury was observed until 24 h after the treatment, but the viable cell concentration declined to 68% compared with the control at 96 h.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24650294, 研究期間(年度):2012-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「抗がん剤耐性を示すがん幹細胞へ集積する超音波応答性ナノ粒子を用いたがん根治療法」課題番号24650294\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24650294/24650294seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学環日本海域環境研究センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034518","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学環日本海域環境研究センター"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50019634"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50019634","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24650294/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24650294/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24650294/24650294seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24650294/24650294seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"OC-PR-SHIMIZU-N-kanen 2014-6p.pdf","filesize":[{"value":"278.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"OC-PR-SHIMIZU-N-kanen 2014-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34531/files/OC-PR-SHIMIZU-N-kanen 2014-6p.pdf"},"version_id":"fc96e21d-5216-427d-8832-1922fbfbd890"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗がん剤耐性を示すがん幹細胞へ集積する超音波応答性ナノ粒子を用いたがん根治療法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗がん剤耐性を示すがん幹細胞へ集積する超音波応答性ナノ粒子を用いたがん根治療法"},{"subitem_title":"Targeted sonocatalytic cancer cell injury using avidin-conjugated titanium dioxide nanoparticles","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34531","relation_version_is_last":true,"title":["抗がん剤耐性を示すがん幹細胞へ集積する超音波応答性ナノ粒子を用いたがん根治療法"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:24:34.177062+00:00"}