{"created":"2023-07-27T06:44:20.514361+00:00","id":34532,"links":{},"metadata":{"_buckets":{"deposit":"65af8cbf-e69f-4bb9-bed1-41f2931e0cad"},"_deposit":{"created_by":3,"id":"34532","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34532"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034532","sets":["2812:2813:2820"]},"author_link":["21405"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝細胞癌の再発、転移など、難治性に関わる重要な細胞集団として癌幹細胞が知られている。本研究ではEpCAM陽性癌幹細胞における遺伝子変異を全エクソンレベルで網羅的に解析した。EpCAM陽性癌幹細胞を有する肝癌では癌抑制遺伝子であるTP53の変異が認められ、さらに個体特異的にARIDやCDKNなど癌の未分化性、細胞周期に関わる遺伝子に変異が認められ、肝癌の難治性を克服する上で重要な分子標的と考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"Recent evidences suggest that hepatocellular carcinoma possesses cancer stem cells that play a pivotal role on local recurrence and distant organ metastasis after radical treatment. In this study, we evaluated the genetic mutations observed in hepatocellular carcinoma containing EpCAM-positive cancer stem cells at whole exome level. We identified TP53, ARID, and CDKN mutations in EpCAM-positive hepatocellular carcinoma cells. These mutations may be responsible for the maintenance of EpCAM-positive cancer stem cells and therefore may be good targets for eradication of hepatocellular carcinoma.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23590967, 研究期間(年度):2011–2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肝癌幹細胞発生に関わるゲノム異常の網羅的解析」課題番号23590967\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590967/23590967seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034519","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学大学病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90377432"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90377432","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590967/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590967/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590967/23590967seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590967/23590967seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-YAMASHITA-T-kaken 2014-5p.pdf","filesize":[{"value":"141.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-YAMASHITA-T-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34532/files/HO-PR-YAMASHITA-T-kaken 2014-5p.pdf"},"version_id":"df753980-b450-45d0-bb21-af74909c23af"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝癌幹細胞発生に関わるゲノム異常の網羅的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝癌幹細胞発生に関わるゲノム異常の網羅的解析"},{"subitem_title":"Whole Exome Analysis of EpCAM-positive Hepatocellular Carcinoma Stem Cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34532","relation_version_is_last":true,"title":["肝癌幹細胞発生に関わるゲノム異常の網羅的解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:24:32.614426+00:00"}