{"created":"2023-07-27T06:44:20.610297+00:00","id":34534,"links":{},"metadata":{"_buckets":{"deposit":"24f38879-b9b4-4887-8a7c-21dce2a88bef"},"_deposit":{"created_by":3,"id":"34534","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34534"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034534","sets":["2812:2813:2820"]},"author_link":["76757","259"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ナルコレプシーは強い眠気と情動性脱力発作（カタプレキシー）を主症状とする睡眠障害であり、その病態にオレキシン産生ニューロン（オレキシンニューロン）の変性・脱落が関わる。しかし、オレキシンニューロンがナルコレプシーを抑制するメカニズムは不明であった。 本研究ではマウスにおいて、青斑核・ノルアドレナリンニューロンと背側逢線核・セロトニンニューロンがオレキシンニューロンの下流で働き、前者は強い眠気、後者はカタプレキシーを抑制することを明らかにした。また、これらのニューロンを人為的に活性化してナルコレプシーを抑制する方法を開発した。","subitem_description_type":"Abstract"},{"subitem_description":"The loss of orexin neurons in humans is associated with narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and cataplexy. However, the precise neural mechanisms downstream of orexin neurons remain unknown.\nWe found that the locus coeruleus noradrenergic and dorsal raphe serotonergic neurons play differential roles in the regulation of sleep/wakefulness by orexin neurons: the former stabilizes wakefulness episodes (reduce sleepiness) and the latter suppresses cataplexy in mice. In addition, we developed a system to suppress narcolepsy in mice by artificially activating these neurons using recombinant AAV vectors and an artificial GPCR called DREADD.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23659134, 研究期間(年度):2011–2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「AAVベクターと人工GPCRを用いたナルコレプシーの遺伝子治療法の開発」課題番号23659134\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659134/23659134seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034521","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20296552"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20296552","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659134/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659134/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659134/23659134seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659134/23659134seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-MIEDA-M-kanen 2014-4p.pdf","filesize":[{"value":"391.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIEDA-M-kanen 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34534/files/ME-PR-MIEDA-M-kanen 2014-4p.pdf"},"version_id":"90e3db22-8d3a-447a-9ced-a0c2cf8b79bf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"AAVベクターと人工GPCRを用いたナルコレプシーの遺伝子治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AAVベクターと人工GPCRを用いたナルコレプシーの遺伝子治療法の開発"},{"subitem_title":"Development of a novel gene therapy on narcolepsy using AAV vectors and artificial GPCRs","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34534","relation_version_is_last":true,"title":["AAVベクターと人工GPCRを用いたナルコレプシーの遺伝子治療法の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:24:29.786135+00:00"}