{"created":"2023-07-27T06:44:21.567837+00:00","id":34554,"links":{},"metadata":{"_buckets":{"deposit":"62743562-becb-4b68-b212-512ee0699b0e"},"_deposit":{"created_by":3,"id":"34554","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34554"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034554","sets":["2812:2813:2821"]},"author_link":["72","25651"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-04-01 – 2013-03-31","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"中枢神経の再生可能なサカナの視神経切断モデルを使用し、再生初期に発現が上昇する遺伝子を同定し、細胞生存や神経突起伸長作用を確認し、これらを神経再生初期分子とした。この候補物質としてHSP70, レチノール結合蛋白プルプリンを同定した。これらに引き続いてレチノイン酸シグナル分子の発現が上昇した。これら再生分子を成熟ラット網膜に導入することにより、ラット視神経がin vivoで再生できた。","subitem_description_type":"Abstract"},{"subitem_description":"Regeneration-associated genes (RAGs) were cloned from axotomized zebrafish retina. HSP70 (a stress protein) and purpurin (a retinol-binding protein) were rapidly induced in the fish retina after optic nerve injury. HSP70 was involved in cell survival of injured retinal ganglion cells (RGCs), whereas purpurin was involved in neurite sprouting from injured RGCs. These RAGs could easily induce regrowth of axotomized optic nerve in adult rat.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「ChIP-on-chip 法による再生初期遺伝子群の同定とラット視神経再生への応用」研究課題番号22300109\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22300109/22300109seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034541","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10019614"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10019614","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300109/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300109/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22300109/22300109seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22300109/22300109seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-KATO-S-kanen 2014-4p.pdf","filesize":[{"value":"266.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KATO-S-kanen 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34554/files/ME-PR-KATO-S-kanen 2014-4p.pdf"},"version_id":"40efe612-ed69-40a0-b83d-8c54e964ca7c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ChIP-on-chip 法による再生初期遺伝子群の同定とラット視神経再生への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ChIP-on-chip 法による再生初期遺伝子群の同定とラット視神経再生への応用"},{"subitem_title":"Identification of regeneration-associated genes in zebrafish by a ChIP-on-chip assay and its application to mammals","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34554","relation_version_is_last":true,"title":["ChIP-on-chip 法による再生初期遺伝子群の同定とラット視神経再生への応用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:36:24.874139+00:00"}