{"created":"2023-07-27T06:44:21.712828+00:00","id":34557,"links":{},"metadata":{"_buckets":{"deposit":"c09c5e6d-a034-41ac-83e8-0fc8e3d83d64"},"_deposit":{"created_by":3,"id":"34557","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34557"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034557","sets":["2812:2813:2821"]},"author_link":["84169","29"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"トランスポーターは栄養物等を細胞内に取り込み、異物等を排出する膜タンパク質である。Oligopeptide transporter (PEPT) はジ・トリペプチドを細胞内に取り込み、腫瘍に高発現することが知られるトランスポーターである。我々は以前にPEPTを標的としたin vivo 腫瘍イメージングと腫瘍増殖抑制ペプチドの合成に成功した。本研究では、PEPT、PEPT と裏打ちタンパク質との相互作用、裏打ちタンパク質と他のトランスポーターとの相互作用の計3つを標的とする抗腫瘍薬の開発を目指し、その基盤となる知見を得た。","subitem_description_type":"Abstract"},{"subitem_description":"Transporters play pivotal roles in both uptake of nutrients and efflux of metabolites/xenobiotics in the body. Oligopeptide transporters (PEPT) function as an uptake mechanism for both dipeptides and tripeptides. PEPTs are known to be highly expressed in a certain types of cancer cells probably to maintain its extremely rapid growth by uptake of nutrients. We have previously succeeded in synthesis of both tumor-imaging substrate and anti-tumor peptides targeted to PEPTs. In the present study we aimed to establish antitumor drugs with triple targets of PEPTs and its associated proteins.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23659019, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ペプチドトランスポーターを利用した腫瘍細胞トリプルブロック分子標的薬の開発」研究課題番号23659019\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659019/23659019seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034544","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30251440"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30251440","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659019/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659019/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659019/23659019seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659019/23659019seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"PH-PR-KATO-Y-kaken-2013-4p.pdf","filesize":[{"value":"512.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-KATO-Y-kaken-2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34557/files/PH-PR-KATO-Y-kaken-2013-4p.pdf"},"version_id":"3d8af672-bd76-42f2-b83d-5eeb78b2d79c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ペプチドトランスポーターを利用した腫瘍細胞トリプルブロック分子標的薬の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ペプチドトランスポーターを利用した腫瘍細胞トリプルブロック分子標的薬の開発"},{"subitem_title":"Development of triple-target antitumor drugs recognized by oligopeptide transporters","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34557","relation_version_is_last":true,"title":["ペプチドトランスポーターを利用した腫瘍細胞トリプルブロック分子標的薬の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:43:50.043149+00:00"}