{"created":"2023-07-27T06:44:22.292788+00:00","id":34569,"links":{},"metadata":{"_buckets":{"deposit":"8a58270f-15c4-4e4f-9a04-9dedd30bff7e"},"_deposit":{"created_by":3,"id":"34569","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34569"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034569","sets":["2812:2813:2821"]},"author_link":["72722","266"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"先天性と考えられた徐脈症例 58 例の genome DNA および臨床データを集積した。56 症例中 26例(45%)に家族歴が認められ、ペースメーカー植込み症例は 24 例(41%)であった。遺伝子解析の結果、58 症例中 7 症例(12%)で遺伝子変異が認められ、これらの症例では QT 延長、心房細動、筋ジストロフィなどの合併が認められた。4 種類のイオンチャネル遺伝子変異に対してパッチクランプ法による電気生理学的検討を行ったところ、3 種類の変異で機能異常が認められた。マウス新生仔心筋より心筋前駆細胞の培養を行ったところ、一部の細胞で自己拍動が認められ、遅延整流 K 電流および内向き整流 K 電流の発現が認められた。","subitem_description_type":"Abstract"},{"subitem_description":"We evaluated clinical characteristics and performed gene analysis for 58 patients with inherited bradyarrhythmia. Twenty six patients (45%) had family history of bradyarrhythmia and 24 patients (41%) underwent pacemaker implantation. Gene analysis showed mutations were found in 7 patients (12%) who were complicated by QT prolongation, atrial fibrillation, or muscular dystrophy. Cellular electrophysiological study showed functional abnormality in 3 of 4 ion channel gene mutations. We isolated cardiosphere-derived cells from the neonatal mouse heart and confirmed that some cells contracted spontaneously. Patch clamp and RT-PCR showed that at least two types of ionic currents were present in mouse cardiosphere-derived cells including a delayed rectifier K+current and an inward rectifier K+current.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22590806, 研究期間(年度):2010–2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「先天性徐脈発症機構の分子生物学的解明とこれに基づくバイオペースメーカー開発の研究」研究課題番号22590806\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590806/22590806seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034556","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00422642"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00422642","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590806/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590806/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590806/22590806seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590806/22590806seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-HAYASHI-K-kaken 2013-6p.pdf","filesize":[{"value":"622.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-HAYASHI-K-kaken 2013-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34569/files/HO-PR-HAYASHI-K-kaken 2013-6p.pdf"},"version_id":"6832c3f4-9389-440d-ad48-d70e644843ec"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"先天性徐脈発症機構の分子生物学的解明とこれに基づくバイオペースメーカー開発の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"先天性徐脈発症機構の分子生物学的解明とこれに基づくバイオペースメーカー開発の研究"},{"subitem_title":"Gene analysis for the inherited bradyarrhythmia and characterization of cardiosphere-derived cells to create biological pacemakers","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34569","relation_version_is_last":true,"title":["先天性徐脈発症機構の分子生物学的解明とこれに基づくバイオペースメーカー開発の研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:43:31.619656+00:00"}