{"created":"2023-07-27T06:44:22.672101+00:00","id":34578,"links":{},"metadata":{"_buckets":{"deposit":"36364959-85f8-4c8b-93c3-ed4cbdab5524"},"_deposit":{"created_by":3,"id":"34578","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34578"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034578","sets":["2812:2813:2821"]},"author_link":["24841","52"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1)マウスマクロファージの培養系を用いて,リガンド添加によるRAGEシグナルがcAMP 依存性シグナル伝達経路によって抑制されることを明らかにした。 (2)cAMP依存性シグナルは,MMP9を活性化し膜結合型RAGEのシェディングを促進することにより,膜結合型RAGEを減少させ可溶型RAGEを増加させることを明らかにした。 (3)cAMP依存性シグナルがRAGEリガンド-RAGE系シグナルを抑制するメカニズムとして,cAMP依存性シグナルによる膜結合型RAGEのシェディング促進が,シグナル伝達に関わる膜結合型RAGE を減少させる一方,デコイ受容体として働く可溶型RAGE を増加させることが考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"(1) We found that ligand-dependent RAGE signal was suppressed by cAMP-dependent signaling pathway, using mouse macrophage culture system.\n(2) We showed that cAMP-dependent signal caused activation of MMP9 that accelerated shedding of membrane-bound form RAGE, which resulted in decrease of membrane-bound form RAGE and increase of soluble form RAGE.\n(3) The mechanism of the suppression of ligand-dependent RAGE signal by cAMP-dependent signal was supposed that the acceleration of shedding of membrane-bound form RAGE via cAMP-dependent signal resulted in decrease of membrane-bound form RAGE functioning signal transducer and increase of soluble form RAGE functioning decoy receptor.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23659430, 研究期間(年度):2011–2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「RAGE阻害薬吸入によるCOPD治療の試み」研究課題番号23659430\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/en/report/KAKENHI-PROJECT-23659430/23659430seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034565","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00115198"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00115198","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659430/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659430/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/en/report/KAKENHI-PROJECT-23659430/23659430seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/en/report/KAKENHI-PROJECT-23659430/23659430seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-YAMAMOTO-H-kaken 2013-4p.pdf","filesize":[{"value":"428.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMAMOTO-H-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34578/files/ME-PR-YAMAMOTO-H-kaken 2013-4p.pdf"},"version_id":"51a8c929-8bba-43c8-8192-8872e429afe2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"RAGE阻害薬吸入によるCOPD治療の試み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RAGE阻害薬吸入によるCOPD治療の試み"},{"subitem_title":"Application of RAGE inhibitor inhalation for COPD","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34578","relation_version_is_last":true,"title":["RAGE阻害薬吸入によるCOPD治療の試み"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:43:20.873775+00:00"}