{"created":"2023-07-27T06:44:22.813407+00:00","id":34581,"links":{},"metadata":{"_buckets":{"deposit":"9d1eb334-dabe-4465-a366-e2a47bae4ed5"},"_deposit":{"created_by":3,"id":"34581","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34581"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034581","sets":["2812:2813:2821"]},"author_link":["22120"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"機能性胃腸症のメカニズムを解析するために、動物モデルを開発し、胃の痛覚に関与する因子を調べた。ラットに反復水回避ストレスを加えると、胃に病変は見られないものの、胃の痛覚が亢進した。痛覚の亢進には副腎皮質刺激ホルモン放出因子(CRF)が関与し、CRF受容体のうちCRF1ではなくCRF2受容体が関与していた。反復水回避ストレスは機能性胃腸症モデルとして有用であり、機能性胃腸症の痛みにはCRF2が重要と思われた。","subitem_description_type":"Abstract"},{"subitem_description":"Repetitive WA-S developed gastric hyperalgesia even in the absence of detectable gastric pathology, suggesting its suitability for a potential animal model of FD. CRF2 receptor play an important role in gastric hyperalgesia observed after the stress. CRF2 receptor signaling may be useful therapeutic targets for FD.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22600004, 研究期間(年度):2010–2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「機能性胃腸症における胃の痛覚過敏に関わるメディエイターの解析」課題番号22600004\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22600004/22600004seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034568","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40244371"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40244371","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22600004/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22600004/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22600004/22600004seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22600004/22600004seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-OZAKI-N-kaken 2013-6p.pdf","filesize":[{"value":"492.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-OZAKI-N-kaken 2013-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34581/files/ME-PR-OZAKI-N-kaken 2013-6p.pdf"},"version_id":"4f713bea-5a60-405f-894f-9cfe15b19a81"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"機能性胃腸症における胃の痛覚過敏に関わるメディエイターの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"機能性胃腸症における胃の痛覚過敏に関わるメディエイターの解析"},{"subitem_title":"Research on basic mechanisms of gastric hyperalgesia in animal model of functional dyspepsia","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34581","relation_version_is_last":true,"title":["機能性胃腸症における胃の痛覚過敏に関わるメディエイターの解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:43:16.025856+00:00"}