{"created":"2023-07-27T06:44:22.860282+00:00","id":34582,"links":{},"metadata":{"_buckets":{"deposit":"224e1865-d483-49de-bff6-b9e84203f3dc"},"_deposit":{"created_by":3,"id":"34582","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34582"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034582","sets":["2812:2813:2821"]},"author_link":["93531","10805"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Nobuaki"}],"nameIdentifiers":[{"nameIdentifier":"93531","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50019634","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50019634"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がん細胞を特異的に認識・結合する生体分子(DNAアプタマー、アビジン)とポリアクリル酸を固定化した溶液分散型二酸化チタン(TiO2)ナノ粒子を作製した。TiO2に超音波を照射することにより生成するOHラジカルの培養がん細胞に対する細胞傷害効果を検討した。その結果、がん細胞がOHラジカルなどの化学種の強力な酸化作用により有意に損傷を受け、アポトーシスを誘導し細胞死に至ることを確認した。","subitem_description_type":"Abstract"},{"subitem_description":"A new sonodynamic therapy for cancer cells was proposed in this study. The delivery of titanium dioxide (TiO2) nanoparticles (NPs) modified with avidinspecifically recognizing cancer cells and subsequent generation of OH radicals from TiO2 NPs activated by external ultrasound irradiation were studied. The uptake of TiO2 NPs modified with avidin by MCF7 cells was clarified and apoptosis was observed at 6 h after the TiO2/US treatment. Although no apparent cell-injury was observed until 24 h after the treatment, the viable cell concentration had deteriorated to 46% of the control at 96 h.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22300177, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「腫瘍集積型光触媒ナノ粒子の創製と超音波力学的がん治療」課題番号22300177\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22300177/22300177seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034569","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学環日本海域環境研究センター"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50019634"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50019634","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300177/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300177/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22300177/22300177seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22300177/22300177seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 宣明"}],"nameIdentifiers":[{"nameIdentifier":"10805","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50019634","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50019634"},{"nameIdentifier":"50019634","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050019634"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"OC-PR-SHIMIZU-N-kanen 2013-6p.pdf","filesize":[{"value":"399.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"OC-PR-SHIMIZU-N-kanen 2013-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34582/files/OC-PR-SHIMIZU-N-kanen 2013-6p.pdf"},"version_id":"99baed2e-e7d4-4b9b-bcd9-3874e2fa8182"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍集積型光触媒ナノ粒子の創製と超音波力学的がん治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍集積型光触媒ナノ粒子の創製と超音波力学的がん治療"},{"subitem_title":"Sonodynamic cancer therapy with tumor targeting TiO2 nanoparticles","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34582","relation_version_is_last":true,"title":["腫瘍集積型光触媒ナノ粒子の創製と超音波力学的がん治療"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-07-01T05:56:51.420275+00:00"}