{"created":"2023-07-27T06:44:23.899613+00:00","id":34607,"links":{},"metadata":{"_buckets":{"deposit":"98ea04d3-a646-4360-b819-36e9513fc0a1"},"_deposit":{"created_by":3,"id":"34607","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34607"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034607","sets":["2812:2813:2822"]},"author_link":["129","76766"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では,原発性胆汁性肝硬変(PBC)などの肝臓病の病態形成に細胞老化が積極的に関与することを明らかとなった。特にPBCの胆管病変における老化胆管細胞はCCL2, CX3CL1発現の亢進を示し,炎症細胞浸潤と相関していた。また、培養老化胆管細胞は,ケモカイン発現亢進を介して単球や肝星細胞の遊走を促進した。老化胆管細胞が周囲微小環境調節を行い、炎症の持続、悪化に関与すると考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"This study revealed that cellular senescence is involved in the pathogenesis of liver diseases such as primary biliary cirrhosis(PBC). Senescent biliary epithelial cells in inflamed and damaged small bile ducts in PBC show increased expression of chemokines such as CCR2 and CX3CL1. Cultured senescent biliary epithelial cells showed increased expression of various chemokines and induced migration of monocytes and hepatic stellate cells in co-culture. These findings suggests that senescent biliary epithelial cells may play a role in augmentation of inflammation around bile ducts by regulating microenvironment in PBC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21590366, 研究期間(年度):2009–2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細胞老化に着目した肝臓病の新たな解析」課題番号21590366\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590366/21590366seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034594","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70225895","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590366/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590366/21590366seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-SASAKI-M-kaken 2012-5p.pdf","filesize":[{"value":"292.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SASAKI-M-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34607/files/ME-PR-SASAKI-M-kaken 2012-5p.pdf"},"version_id":"b3e9d5dc-50a2-4bb1-a49a-208f787ddb43"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞老化に着目した肝臓病の新たな解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞老化に着目した肝臓病の新たな解析"},{"subitem_title":"Novel approach to liver disease from aspect of cellular senescence","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34607","relation_version_is_last":true,"title":["細胞老化に着目した肝臓病の新たな解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:29:49.800250+00:00"}