{"created":"2023-07-27T06:44:24.091073+00:00","id":34611,"links":{},"metadata":{"_buckets":{"deposit":"962b044b-1557-4a07-82cb-db477f376964"},"_deposit":{"created_by":3,"id":"34611","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34611"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034611","sets":["2812:2813:2822"]},"author_link":["80066","189"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗がん剤と磁場の併用曝露法の有効性を明らかにするため,基礎研究として交流磁場曝露による数種類の抗がん剤作用増強を測定した結果,検討した全ての薬剤で磁場による作用増強が見られ、作用増強率に影響する要因は薬剤の作用機序や半数阻害濃度ではなく分子量であることが示唆された。また,マイトマイシンCとシスプラチンの薬剤2種について,細菌細胞への作用時の交流磁場曝露による作用増強メカニズムを薬剤の細胞膜透過性の点から検討した結果,交流磁場曝露により薬剤の細胞膜の透過性が高まることで各薬剤作用は増強されることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Our results indicated that each potency of cisplatin, mitoxantrone, daunorubicin, actinomycin D, bleomycin, and zinostatin, was enhanced by exposure to 60 Hz, 50 mT magnetic fields. The analysis of the potency of supernatant remaining drugs in the culture medium indicated that the intracellular drug potency was increased and extracellular drug potency was decreased by exposure to magnetic fields. The values of drug potency revealed a significant inverse correlation between intracellular and extracellular cells. The results suggested that magnetic fields(60 Hz, 50 mT) change the permeability of cell membrane and influence the drug intake.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「交流磁場と抗がん剤の併用療法の開発」課題番号22700508\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22700508/22700508seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034598","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学環日本海域環境研究センター"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10359713","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700508/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22700508/22700508seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"TE-PR-KAKIKAWA-M-kaken 2012-5p.pdf","filesize":[{"value":"270.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-KAKIKAWA-M-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34611/files/TE-PR-KAKIKAWA-M-kaken 2012-5p.pdf"},"version_id":"f3ab6776-3b20-4ed5-a5bd-3e3bf269d46e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"交流磁場と抗がん剤の併用療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"交流磁場と抗がん剤の併用療法の開発"},{"subitem_title":"Research of the combined effect of magnetic fields and anticancer drugs","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34611","relation_version_is_last":true,"title":["交流磁場と抗がん剤の併用療法の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:29:44.171750+00:00"}