{"created":"2023-07-27T06:44:24.187742+00:00","id":34613,"links":{},"metadata":{"_buckets":{"deposit":"fd7bc223-4650-4c3d-b22a-08664140e3fe"},"_deposit":{"created_by":3,"id":"34613","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34613"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034613","sets":["2812:2813:2822"]},"author_link":["23232","9956"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がんの浸潤・転移に重要な役割を果たすMT1-MMPの新規基質の探索を行い、その生理・病理的意義を解明した。その結果、膜タンパクの切断・シェディングに特にユニークな活性を見出した。例えば、MT1-MMPによるセリンプロテアーゼ阻害因子Hepatocyte Growth Factor Activator Inhibitor-1の切断はプロテアーゼ活性化カスケイドを始動させ組織破壊を引き起こす。我々はその状態をプロテアーゼストームと名付けた。","subitem_description_type":"Abstract"},{"subitem_description":"We screened new substrates for MT1-MMP, which plays an important role in tumor invasion and metastasis, and analyzed pathophysiologicanl significance of it. These studies demonstrated that cleavage and shedding of membrane proteins by MT1-MMP is quite unique. For example, cleavage of serine protease inhibitor Hepatocyte Growth Factor Activator Inhibitor-1 by MT1-MMP initiates protease activation cascade, which subsequently causes tissue destruction. We named it as protease storm.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「膜型マトリックスメタロプロテアーゼー1のがん悪性化形質に果たす役割の解析」課題番号21390091\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390091/21390091seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034600","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00115239","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390091/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390091/21390091seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-SATO-H-kaken 2012-4p.pdf","filesize":[{"value":"242.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SATO-H-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34613/files/CA-PR-SATO-H-kaken 2012-4p.pdf"},"version_id":"8c08fe56-dbb9-4941-abd1-fc28c0bc34cd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膜型マトリックスメタロプロテアーゼー1のがん悪性化形質に果たす役割の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膜型マトリックスメタロプロテアーゼー1のがん悪性化形質に果たす役割の解析"},{"subitem_title":"Study on role of membrane-type matrix metalloproteinase-1 in tumor malignancy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34613","relation_version_is_last":true,"title":["膜型マトリックスメタロプロテアーゼー1のがん悪性化形質に果たす役割の解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:29:41.235398+00:00"}