{"created":"2023-07-27T06:44:24.283880+00:00","id":34615,"links":{},"metadata":{"_buckets":{"deposit":"c7c01184-482e-4aca-ba04-83b2b7395d97"},"_deposit":{"created_by":3,"id":"34615","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34615"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034615","sets":["2812:2813:2822"]},"author_link":["539"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高比重リポ蛋白(HDL)コレステロールが高い人は(100 mg/dL以上)は本邦の一般人の約1%に見られ,その半数でコレステリルエステル転送蛋白欠損が関与しているが,その他の成因の大部分は不明である。アンジオポエチン様蛋白は内因性のリパーゼインヒビターであり,リパーゼ活性を調節することによりHDL粒子の異化に関与する。アンジオポエチン様蛋白4はリポ蛋白リパーゼのインヒビターとして作用し,アンジオポエチン様蛋白3は血管内皮リパーゼのインヒビターとして作用する。本研究でCETP欠損が除外された高HDL血症45例の末梢血液由来のゲノム遺伝子を用いて,両遺伝子の遺伝子変異の検索を行ったが,変異は同定できなかった。","subitem_description_type":"Abstract"},{"subitem_description":"Increased levels of plasma HDL is frequently found in~ 1% of general Japanese population. Genetic cause of high HDL levels has been uncertain except CETP deficiency. Plasma angiopoietin-like protein 3 and 4 are known as an intrinsic lipase inhibitor against lipoprotein lipase and endothelial lipase, respectively. Although every exon in these two genes was screened in subjects with increased HDL levels but without CETP deficiency, mutation was not found.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21590616, 研究期間(年度):2009–2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「アンジオポエチン様蛋白異常による高高比重リポ蛋白血症の抗動脈硬化性」課題番号21590616\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590616/21590616seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034602","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80293348","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590616/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590616/21590616seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-INAZU-A-kaken 2012-4p.pdf","filesize":[{"value":"180.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-INAZU-A-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34615/files/ME-PR-INAZU-A-kaken 2012-4p.pdf"},"version_id":"785db693-bf84-42f5-9c9e-6852c0f04c3f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アンジオポエチン様蛋白異常による高高比重リポ蛋白血症の抗動脈硬化性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アンジオポエチン様蛋白異常による高高比重リポ蛋白血症の抗動脈硬化性"},{"subitem_title":"Anti-atherogenicity of increeased levels of HDL caused by angiopoietin-like protein gene mutations","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34615","relation_version_is_last":true,"title":["アンジオポエチン様蛋白異常による高高比重リポ蛋白血症の抗動脈硬化性"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:29:33.905952+00:00"}